Emerson S G, Gale R P
Division of Hematology/Oncology, University of Michigan Medical Center, Ann Arbor 48109.
Int J Cell Cloning. 1987 Nov;5(6):432-49. doi: 10.1002/stem.5530050602.
Allogeneic bone marrow transplantation requires that donor stem cells home to the recipient bone marrow, proliferate and differentiate under normal physiologic regulatory mechanisms. Recent observations that T cell depletion of donor bone marrow leads to a greatly increased incidence of graft failure mandate a detailed understanding of the engraftment process. Post-transplant hematopoietic deficiencies appear to be related to several sources: decreased number of stem cells, activation of donor hematopoietic suppressor cells, rejection of donor stem cells by residual recipient lymphocytes and abnormal function of accessory cells that produce hematopoietic growth factors. A better understanding of the relative roles of these factors should lead to a better understanding of engraftment as well as graft failure and its prevention.
异基因骨髓移植要求供体干细胞归巢至受体骨髓，在正常生理调节机制下增殖并分化。最近的观察发现，对供体骨髓进行T细胞清除会导致移植失败的发生率大幅增加，这就需要对植入过程有详细的了解。移植后造血功能缺陷似乎与多种因素有关：干细胞数量减少、供体造血抑制细胞的激活、残留受体淋巴细胞对供体干细胞的排斥以及产生造血生长因子的辅助细胞功能异常。更好地理解这些因素的相对作用，应该有助于更好地理解植入过程以及移植失败及其预防。
