Grzegorowska Oliwia, Lorkowski Jacek
Department of Cardiology, Independent Public Regional Hospital, 71-455 Szczecin, Poland.
Department of Orthopaedic and Traumatology, Central Clinical Hospital of Ministry of Interior, 02-507 Warsaw, Poland.
J Clin Med. 2020 Nov 21;9(11):3746. doi: 10.3390/jcm9113746.
An outbreak of SARS-CoV-2 infection in December 2019 became a major global concern in 2020. Since then, several articles analyzing the course, complications and mechanisms of the infection have appeared. However, there are very few papers explaining the possible correlations between COVID-19, atherosclerosis and acute coronary syndromes. We performed an analysis of PubMed, Cochrane, Google Scholar, and MEDLINE databases. As of September 15, 2020, the results were as follows: for "COVID-19" and "cardiovascular system" we obtained 687 results; for "COVID-19" and "myocardial infarction" together with "COVID-19" and "acute coronary syndrome" we obtained 328 results; for "COVID-19" and "atherosclerosis" we obtained 57 results. Some of them did not fulfill the search criteria or concerned the field of neurology. Only articles written in English, German and Polish were analyzed for a total number of 432 papers. While the link between inflammatory response, COVID- 19 and atherosclerosis still remains unclear, there is evidence that suggests a more likely correlation between them. Practitioners' efforts should be focused on the prevention of excessive inflammatory response and possible complications, while there are limited specific therapeutic options against SARS-CoV-2. Furthermore, special attention should be paid to cardioprotection during the pandemic.
2019年12月爆发的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染在2020年成为全球主要关注的问题。从那时起，出现了几篇分析该感染病程、并发症及机制的文章。然而，解释2019冠状病毒病（COVID-19）、动脉粥样硬化和急性冠状动脉综合征之间可能关联的论文非常少。我们对PubMed、Cochrane、谷歌学术和MEDLINE数据库进行了分析。截至2020年9月15日，结果如下：对于“COVID-19”和“心血管系统”，我们获得687条结果；对于“COVID-19”和“心肌梗死”以及“COVID-19”和“急性冠状动脉综合征”，我们获得328条结果；对于“COVID-19”和“动脉粥样硬化”，我们获得57条结果。其中一些不符合检索标准或涉及神经学领域。仅分析了用英语、德语和波兰语撰写的文章，共计432篇。虽然炎症反应、COVID-19和动脉粥样硬化之间的联系仍不明确，但有证据表明它们之间更有可能存在关联。从业者的努力应集中在预防过度炎症反应和可能的并发症上，而针对SARS-CoV-2的特异性治疗选择有限。此外，在疫情期间应特别关注心脏保护。
