新型冠状病毒肺炎与：新的致动脉粥样硬化因素？一例病例报告及尸检结果

COVID-19 and : New Atherogenic Factor? A Case Report and Autopsy Findings.

作者信息

Macarova Julia A, Malakhova Sofia A, Novitskaya Tatiana A, Shapkina Valeria A, Churilov Leonid P

机构信息

Laboratory of the Microangiopathic Mechanisms of Atherogenesis, Saint Petersburg State University, 199034 Saint-Petersburg, Russia.

Department of Experimental Tuberculosis, St. Petersburg State Research Institute of Phthisiopulmonology, 191036 Saint-Petersburg, Russia.

出版信息

Diagnostics (Basel). 2023 Mar 14;13(6):1097. doi: 10.3390/diagnostics13061097.

DOI:10.3390/diagnostics13061097

PMID:36980405

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10047382/

Abstract

Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration of the blood vessels, including . A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated by a stroke during COVID-19 infection is briefly described. The results of the autopsy showed perivascular lymphocytic infiltration and signs of vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in the context of the concept giving the important role in atherogenesis to .

摘要

新冠病毒病患者出现心血管并发症的几率更高，包括血栓形成和血栓栓塞。有人可能认为，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的作用会将稳定的动脉粥样硬化斑块转变为不稳定状态。新冠病毒病中的心血管并发症可能是由血管的进行性病毒改变引起的，包括……简要描述了一例由脑动脉粥样硬化引起、在新冠病毒感染期间因中风而加重的致命缺血性脑病病例。尸检结果显示血管周围淋巴细胞浸润以及外膜微血管血栓形成的血管炎迹象。本文所讨论的数据是在一个概念的背景下进行解读的，该概念认为……在动脉粥样硬化形成中起重要作用。