Li Kai, Zhu Yuting, Zhang Qiang, Shi Xiaoli, Liang Feng, Han Dong
The State Key Laboratory for Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.
Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Materials (Basel). 2020 Nov 21;13(22):5277. doi: 10.3390/ma13225277.
Although there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple strategy, with a structure highly similar to that of the ECM. Cell viability experiments showed that the hydrogel not only has good biocompatibility but also promotes cell proliferation and growth. It was also observed that cells adhere to the fibers in the hydrogel, mimicking the state of cells in the ECM. Lastly, through a rat skin wound repair experiment, we demonstrated that this hydrogel has a good effect on promoting rat skin healing. Its high structural similarity to the ECM and good biocompatibility make this hydrogel a good candidate for prospective applications in the field of tissue engineering.
尽管已经有许多关于使用水凝胶作为天然细胞外基质（ECM）替代品的研究，但模仿ECM结构和特性的水凝胶在当前研究中仍然是一个有争议的话题。在此，我们采用一种简单的策略制备了一种分级仿生纤维水凝胶，其结构与ECM高度相似。细胞活力实验表明，该水凝胶不仅具有良好的生物相容性，还能促进细胞增殖和生长。还观察到细胞粘附在水凝胶中的纤维上，模仿了细胞在ECM中的状态。最后，通过大鼠皮肤伤口修复实验，我们证明了这种水凝胶对促进大鼠皮肤愈合有良好效果。其与ECM的高度结构相似性和良好的生物相容性使这种水凝胶成为组织工程领域潜在应用的良好候选者。
