Zhang Yu Shrike, Khademhosseini Ali
Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science. 2017 May 5;356(6337). doi: 10.1126/science.aaf3627.
Hydrogels are formed from hydrophilic polymer chains surrounded by a water-rich environment. They have widespread applications in various fields such as biomedicine, soft electronics, sensors, and actuators. Conventional hydrogels usually possess limited mechanical strength and are prone to permanent breakage. Further, the lack of dynamic cues and structural complexity within the hydrogels has limited their functions. Recent developments include engineering hydrogels that possess improved physicochemical properties, ranging from designs of innovative chemistries and compositions to integration of dynamic modulation and sophisticated architectures. We review major advances in designing and engineering hydrogels and strategies targeting precise manipulation of their properties across multiple scales.
水凝胶由被富水环境包围的亲水性聚合物链形成。它们在生物医学、软电子学、传感器和致动器等各个领域都有广泛应用。传统水凝胶通常机械强度有限,容易发生永久性断裂。此外,水凝胶内部缺乏动态线索和结构复杂性限制了它们的功能。最近的进展包括设计具有改进物理化学性质的工程水凝胶,范围从创新化学和组成的设计到动态调制和复杂结构的整合。我们综述了水凝胶设计和工程方面的主要进展以及针对跨多个尺度精确调控其性质的策略。