From the Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles.
Division of Breast, Endocrine, and Soft Tissue Surgery.
Ann Plast Surg. 2021 Mar 1;86(3S Suppl 2):S336-S341. doi: 10.1097/SAP.0000000000002592.
Soft tissue sarcomas are a heterogenous group of malignant tumors that represent approximately 1% of adult malignancies. Although these tumors occur throughout the body, the majority involved the lower extremity. Management may involve amputation but more commonly often includes wide local resection by an oncologic surgeon and involvement of a plastic surgeon for reconstruction of larger and more complex defects. Postoperative wound complications are challenging for the surgeon and patient but also impact management of adjuvant chemotherapy and radiation therapy. To explore risk factors for wound complications, we reviewed our single-institution experience of lower-extremity soft tissue sarcomas from April 2009 to September 2016. We identified 127 patients for retrospective review and analysis. The proportion of patients with wound complications in the cohort was 43.3%. Most notably, compared with patients without wound complications, patients with wound complications had a higher proportion of immediate reconstruction (34.5% vs 15.3%; P = 0.05) and a marginally higher proportion who received neoadjuvant radiation (30.9% vs 16.7%; P = 0.06).
软组织肉瘤是一组异质性的恶性肿瘤，占成人恶性肿瘤的 1%左右。虽然这些肿瘤可以发生在全身各处，但大多数发生在下肢。治疗方法可能包括截肢，但更常见的是由肿瘤外科医生进行广泛的局部切除，并由整形医生进行更大、更复杂的缺损重建。术后伤口并发症对外科医生和患者都是一个挑战，但也会影响辅助化疗和放疗的管理。为了探讨伤口并发症的危险因素，我们回顾了 2009 年 4 月至 2016 年 9 月我们机构治疗的下肢软组织肉瘤患者的单中心经验。我们回顾性分析了 127 例患者。该队列中发生伤口并发症的患者比例为 43.3%。值得注意的是，与没有伤口并发症的患者相比，有伤口并发症的患者中即刻重建的比例更高（34.5% vs. 15.3%；P=0.05），且接受新辅助放疗的比例也略有升高（30.9% vs. 16.7%；P=0.06）。
