Department of Clinical and Molecular Medicine, St. Olavs Hospital, NTNU - Norwegian University of Science and Technology, Lab Center 3 East, 7006, Trondheim, Norway.
Department of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Sci Rep. 2020 Nov 24;10(1):20416. doi: 10.1038/s41598-020-77432-0.
Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a population-based setting. Data from the prospective Nord-Trøndelag Health Study (HUNT2: 1995-1997 and HUNT3: 2006-2008) were used. wGRS added each participant's carriage of all risk variants weighted by the coefficient from published association studies. Published wGRS for CAD and RA were analysed in Cox regression with MI as outcome, age as analysis time, and censoring at the first MI, death, or 31.12.2017. 2609 of 61,465 participants developed MI during follow-up (mean 17.7 years). The best-fitting wGRS for CAD and RA included 157 and 27 single-nucleotide polymorphisms, respectively. In multivariable analysis including traditional CAD risk factors, the CAD wGRS was associated with MI [hazard ratio = 1.23 (95% CI 1.18-1.27) for each SD increase, p < 0.0001] in RA patients (n = 433) and controls. The RA wGRS was not significant (p = 0.06). Independently from traditional risk factors, a CAD wGRS was significantly associated with the risk for MI in RA patients and controls, whereas an RA wGRS was not. The captured genetic risk for RA contributed little to the risk of MI.
类风湿关节炎（RA）患者发生心肌梗死（MI）的风险增加。在基于人群的环境中，尚不清楚 MI 与冠状动脉疾病（CAD）和 RA 的加权遗传风险评分（wGRS）的重叠关联。使用前瞻性北特伦德拉格健康研究（HUNT2：1995-1997 年和 HUNT3：2006-2008 年）的数据。wGRS 为每个参与者携带的所有风险变异赋予了根据已发表的关联研究系数加权的权重。在 Cox 回归中分析了 CAD 和 RA 的已发表 wGRS，MI 作为结局，年龄作为分析时间，并且在首次 MI、死亡或 2017 年 12 月 31 日截止。在随访期间，61465 名参与者中有 2609 人发生 MI（平均 17.7 年）。CAD 和 RA 的最佳拟合 wGRS 分别包含 157 个和 27 个单核苷酸多态性。在包括传统 CAD 危险因素的多变量分析中，CAD wGRS 与 MI 相关[风险比=1.23（95%CI 1.18-1.27），每增加一个 SD，p<0.0001]在 RA 患者（n=433）和对照组中。RA wGRS 无显著意义（p=0.06）。独立于传统危险因素，CAD wGRS 与 RA 患者和对照组 MI 风险显著相关，而 RA wGRS 则无显著相关性。RA 的 CAD 遗传风险对 MI 风险的贡献很小。
