Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, Shenyang 110840, China.
Gene. 2013 Sep 10;526(2):134-41. doi: 10.1016/j.gene.2013.05.002. Epub 2013 May 16.
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the major enzymes responsible for alcohol metabolism in humans. Emerging evidences have shown that functional polymorphisms in ADH and ALDH genes might play a critical role in increasing coronary artery disease (CAD) and myocardial infarction (MI) risks; however, individually published studies showed inconclusive results. The aim of this meta-analysis is to evaluate the associations between the genetic polymorphisms of ADH and ALDH genes with susceptibility to CAD and MI. A literature search was conducted on PubMed, Embase, Web of Science and Chinese BioMedical databases from inception through December 1st, 2012. Crude relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Twelve case-control studies were included with a total of 9616 subjects, including 2053 CAD patients, 1436 MI patients, and 6127 healthy controls. Meta-analysis showed that mutant genotypes (GA+AA) of the rs671 polymorphism in the ALDH2 gene were associated with increased risk of both CAD and MI (CAD: RR=1.20, 95%CI: 1.03-1.40, P=0.021; MI: RR=1.32, 95%CI: 1.11-1.57, P=0.002). However, there were no significant associations of ADH genetic polymorphisms to CAD and MI risks (CAD: RR=0.92, 95%CI: 0.73-1.15, P=0.445; MI: RR=0.93, 95%CI: 0.84-1.03, P=0.148). In conclusion, this meta-analysis provides strong evidence that ALDH2 rs671 polymorphism may be associated with increased risks of CAD and MI. However, further studies are still needed to accurately determine whether ADH genetic polymorphisms are associated with susceptibility to CAD and MI.
乙醇脱氢酶（ADH）和醛脱氢酶（ALDH）是人类酒精代谢的主要酶。新出现的证据表明，ADH 和 ALDH 基因的功能多态性可能在增加冠心病（CAD）和心肌梗死（MI）风险方面发挥关键作用；然而，单独发表的研究结果并不一致。本荟萃分析旨在评估 ADH 和 ALDH 基因的遗传多态性与 CAD 和 MI 易感性之间的关系。我们在 PubMed、Embase、Web of Science 和中国生物医学文献数据库中进行了文献检索，检索时间截至 2012 年 12 月 1 日。计算了粗相对风险（RR）和 95%置信区间（CI）。共纳入 12 项病例对照研究，共 9616 例患者，包括 2053 例 CAD 患者、1436 例 MI 患者和 6127 例健康对照。荟萃分析显示，ALDH2 基因 rs671 多态性的突变基因型（GA+AA）与 CAD 和 MI 的风险增加相关（CAD：RR=1.20，95%CI：1.03-1.40，P=0.021；MI：RR=1.32，95%CI：1.11-1.57，P=0.002）。然而，ADH 基因多态性与 CAD 和 MI 风险无显著相关性（CAD：RR=0.92，95%CI：0.73-1.15，P=0.445；MI：RR=0.93，95%CI：0.84-1.03，P=0.148）。综上所述，本荟萃分析提供了有力证据表明，ALDH2 rs671 多态性可能与 CAD 和 MI 的风险增加相关。然而，仍需要进一步的研究来准确确定 ADH 基因多态性是否与 CAD 和 MI 的易感性相关。
