Singh Desh Deepak, Han Ihn, Choi Eun-Ha, Yadav Dharmendra Kumar
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
Plasma Bioscience Research Center, Applied Plasma Medicine Center, Department of Electrical & Biological Physics, Kwangwoon University, Seoul, Republic of Korea.
Comput Struct Biotechnol J. 2020;18:3774-3787. doi: 10.1016/j.csbj.2020.11.011. Epub 2020 Nov 20.
Coronaviruses are a group of enveloped RNA viruses that are diversely found in humans and now declared a global pandemic by the World Health Organization in March 2020. The population's susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks, evolved into public health events, and rapidly transmitted globally. Thus, there is an urgent need to develop effective therapies and vaccines against this disease. In the primary stage of severe acute respiratory syndrome coronavirus (SARS-COV-2) infection, the signs and symptoms are nonspecific, and many more cases have been observed than initially expected. Genome sequencing is performed regularly to identify genetic changes to SARS-COV-2, and vaccine development is focused on manufacture, production, and based on specific problems, and very few are available on recent developments in the prevention of outbreaks. The aim of this review article to explore recent updates on SARS-COV-2 in the context of pathogenesis during disease progression, and innate acquired mechanisms of defense, This includes advances in diagnostics, susceptibility, and severity of host-virus genome interactions, modes of transmission, active compounds being used in pre-clinical and clinical trials for the treatment of patients, vaccine developments, and the effectiveness of SARS-COV-2 prevention and control measures. We have summarized the importance of pathophysiology immune response, Diagnostics, vaccine development currently approaches explored for SARS-COV-2.
冠状病毒是一组包膜RNA病毒，在人类中广泛存在，2020年3月被世界卫生组织宣布为全球大流行病。人群对这些高致病性冠状病毒的易感性导致了大规模疫情爆发，演变成公共卫生事件，并在全球迅速传播。因此，迫切需要开发针对这种疾病的有效疗法和疫苗。在严重急性呼吸综合征冠状病毒（SARS-COV-2）感染的初期，症状和体征不具特异性，实际观察到的病例比最初预期的要多得多。定期进行基因组测序以识别SARS-COV-2的基因变化，疫苗研发聚焦于制造、生产，并基于特定问题展开，而关于预防疫情爆发的最新进展的报道却很少。这篇综述文章的目的是探讨在疾病进展过程中SARS-COV-2发病机制、固有和获得性防御机制方面的最新进展，这包括诊断、易感性、宿主-病毒基因组相互作用的严重程度、传播方式、用于治疗患者的临床前和临床试验中的活性化合物、疫苗研发以及SARS-COV-2预防和控制措施的有效性。我们总结了病理生理免疫反应、诊断、目前针对SARS-COV-2探索的疫苗研发方法的重要性。
