Guo Jun, Wang Fu, Zhou Qing, Geng Qiang, Gao Qinghe, Zhang Rui, Zhang Chunhe, Xuan Zhihua, Cai Jian, Bin Bin, Han Qiang, Guo Boda, Yan Bin, Zhang Jiwei, Colonnello Elena, Jannini Emmanuele A
Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Department of Andrology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Andrologia. 2021 Feb;53(1):e13915. doi: 10.1111/and.13915. Epub 2020 Nov 24.
To evaluate the safety and efficacy of Chinese medicine, Qiaoshao formula combined with dapoxetine was used for the treatment of premature ejaculation in a real-life setting. Nine hundred and five males diagnosed with premature ejaculation were reviewed in this retrospective cohort study. We divided the patients into two groups: dapoxetine alone and Qiaoshao formula combined with dapoxetine according to actual interventions provided to patients in clinics. The perceived intravaginal ejaculation latency time and the premature ejaculation profile measures markedly improved in both groups. However, in men with severe premature ejaculation (baseline perceived intravaginal ejaculation latency time <1 min) and those with baseline age ≤30 years, the perceived intravaginal ejaculation latency time was slightly but significantly longer with combined therapy than with dapoxetine alone (p < .05). Therefore, combined therapy involving the Qiaoshao formula and dapoxetine proved to safe as well as effective for treating premature ejaculation while prolonging the perceived intravaginal ejaculation latency time, which significantly improved the overall satisfaction of the patient and likely that of the couple.
为评估中药翘芍方联合达泊西汀治疗早泄的安全性和有效性，在实际临床环境中进行了相关研究。本回顾性队列研究纳入了905例确诊为早泄的男性患者。根据临床实际给予患者的干预措施，将患者分为两组：单纯达泊西汀组和翘芍方联合达泊西汀组。两组患者的阴道内射精潜伏期（IELT）和早泄概况测量值均有显著改善。然而，在重度早泄（基线IELT＜1分钟）且基线年龄≤30岁的男性中，联合治疗组的IELT略长但显著长于单纯达泊西汀组（p＜0.05）。因此，翘芍方联合达泊西汀治疗早泄安全有效，可延长IELT，显著提高患者及伴侣的总体满意度。
