School of Pediatrics, University of Cagliari, Cagliari, Italy.
Neonatal Intensive Care Unit AOU, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
Pediatr Allergy Immunol. 2020 Nov;31 Suppl 26:5-7. doi: 10.1111/pai.13360.
Human microbiome contributes to critical functions that impact health and disease. It influences the development of the immune system, and the pathogenesis of immunological disorders included allergy. While it is easy to understand how airway microbiome, influencing local inflammation and immune activity, could contribute to shaping asthma phenotype, it is not so obvious to understand the influence by the gut microbiome, but there is growing evidence about it. The increase of allergic disorders in western countries led to investigate the role environment is playing and how it may change our microbiome and immune system, with the hope of finding new preventive approaches for allergy.
人类微生物组对影响健康和疾病的关键功能有贡献。它影响免疫系统的发育，包括过敏在内的免疫紊乱的发病机制。虽然很容易理解影响局部炎症和免疫活性的气道微生物组如何有助于塑造哮喘表型，但理解肠道微生物组的影响并不那么明显，但有越来越多的证据表明这一点。西方国家过敏疾病的增加促使人们研究环境所起的作用以及它如何改变我们的微生物组和免疫系统，希望为过敏找到新的预防方法。
