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超声引导下经皮静脉内激光治疗联合硬化治疗治疗巨大肌内静脉畸形。

Ultrasound-guided percutaneous endovenous laser treatment combined with sclerotherapy for the treatment of large intramuscular venous malformations.

机构信息

Department of Angiology, Center for Malformation and Rare Vascular Diseases, Lausanne University Hospital (CHUV), Lausanne, Switzerland -

Department of Pediatric Surgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

出版信息

Int Angiol. 2021 Feb;40(1):1-8. doi: 10.23736/S0392-9590.20.04549-6. Epub 2020 Nov 25.

Abstract

BACKGROUND

Among vascular anomalies, congenital venous malformations (VMs) are the most common lesions. Treatment of VMs is sometimes difficult or cumbersome, depending on their size and tissue involvement. Surgery may lead to invasive and mutilating excisions, often allowing only partial removal, with an increased risk of recurrence. Sclerotherapy is a mainstream technique, resulting in endothelium destruction, fibrosis and subsequent shrinkage of the vascular lesion, also with a risk of recurrence. However, this technique may not be efficient in cases of large and infiltrating VMs. Endovenous thermal ablation has been found to be more effective than sclerotherapy for transmural vascular destruction and has therefore been employed in the treatment of VMs.

METHODS

In this study we described a combined technique for the treatment of large intramuscular VMs in seven consecutive patients, associating endovenous laser ablation with sclerotherapy. The aim was to assess feasibility and safety of the procedure.

RESULTS

We reported a high immediate technical success, clinical and radiological improvement, with no complications.

CONCLUSIONS

The preliminary results presented herein show, that combining EVLA and sclerotherapy for the treatment of voluminous persistent intramuscular VM is safe and technically feasible. The combination of a wide direct intimal thermal damage with chemical sclerotherapy is the force of this approach. The small number of cases and the medium term follow up represent though a limitation.

摘要

背景

在血管畸形中,先天性静脉畸形(VM)是最常见的病变。VM 的治疗有时较为困难或棘手,具体取决于其大小和组织受累程度。手术可能导致侵袭性和致残性切除,通常仅允许部分切除,且复发风险增加。硬化疗法是一种主流技术,可导致内皮细胞破坏、纤维化和随后的血管病变收缩,也有复发的风险。然而,这种技术在大而浸润性 VM 的情况下可能效果不佳。静脉内热消融已被发现比硬化疗法更有效地用于透壁血管破坏,因此已被用于 VM 的治疗。

方法

在这项研究中,我们描述了一种联合技术,用于治疗七例连续患者的大型肌内 VM,将静脉内激光消融与硬化疗法相结合。目的是评估该程序的可行性和安全性。

结果

我们报告了高即刻技术成功率、临床和影像学改善,无并发症。

结论

本文介绍的初步结果表明,联合 EVLA 和硬化疗法治疗体积大且持续存在的肌内 VM 是安全且技术可行的。广泛的直接内膜热损伤与化学硬化疗法的结合是这种方法的优势。但病例数量少和中期随访是一个局限性。

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