Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei 100, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei 100, Taiwan.
ACS Appl Mater Interfaces. 2020 Dec 9;12(49):54316-54327. doi: 10.1021/acsami.0c13101. Epub 2020 Nov 25.
infection is one of the leading causes of several gastroduodenal diseases, such as gastritis, peptic ulcer, and gastric cancer. In fact, eradication provides a preventive effect against the incidence of gastric cancer. Amoxicillin is a commonly used antibiotic for eradication. However, due to its easy degradation by gastric acid, it is necessary to administer it in a large dosage and to combine it with other antibiotics. This complexity and the strong side effects of eradication therapy often lead to treatment failure. In this study, the chitosan/poly (acrylic acid) particles co-loaded with superparamagnetic iron oxide nanoparticles and amoxicillin (SPIO/AMO@PAA/CHI) are used as drug nano-carriers for eradication therapy. and results show that the designed SPIO/AMO@PAA/CHI nanoparticles are biocompatible and could retain the biofilm inhibition and the bactericidal effect of amoxicillin against . Moreover, the mucoadhesive property of chitosan allows SPIO/AMO@PAA/CHI nanoparticles to adhere to the gastric mucus layer and rapidly pass through the mucus layer after exposure to a magnetic field. When PAA is added, it competes with amoxicillin for chitosan, so that amoxicillin is quickly and continuously released between the mucus layer and the gastric epithelium and directly acts on . Consequently, the use of this nano-carrier can extend the drug residence time in the stomach, reducing the drug dose and treatment period of eradication therapy.
感染是导致多种胃十二指肠疾病的主要原因之一，如胃炎、消化性溃疡和胃癌。事实上，根除幽门螺杆菌可预防胃癌的发生。阿莫西林是一种常用于根除幽门螺杆菌的抗生素。然而，由于其易被胃酸降解，因此需要大剂量使用，并与其他抗生素联合使用。这种复杂性和根除治疗的强烈副作用往往导致治疗失败。在本研究中，将载有超顺磁性氧化铁纳米颗粒和阿莫西林的壳聚糖/聚丙烯酸共聚物纳米粒子（SPIO/AMO@PAA/CHI）用作根除治疗的药物纳米载体。和结果表明，设计的 SPIO/AMO@PAA/CHI 纳米粒子具有生物相容性，可保留阿莫西林对的生物膜抑制和杀菌作用。此外，壳聚糖的粘液附着特性使 SPIO/AMO@PAA/CHI 纳米粒子在暴露于磁场后能够附着在胃粘液层上并迅速穿透粘液层。当添加 PAA 时，它会与阿莫西林竞争壳聚糖，从而使阿莫西林在粘液层和胃上皮细胞之间快速且持续释放，并直接作用于。因此，使用这种纳米载体可以延长药物在胃中的停留时间，减少根除治疗的药物剂量和治疗周期。
