Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Department of Biostatistics, Seoul National University Boramae Medical Center, Seoul, Korea.
J Womens Health (Larchmt). 2020 Dec;29(12):1500-1506. doi: 10.1089/jwh.2020.8488. Epub 2020 Nov 25.
The sex-related impact of metabolic syndrome (MetS) on obstructive coronary artery disease (OCAD) has not been well evaluated. A total of 1156 patients (62 years and 58% women) with chest pain undergoing invasive coronary angiography (CAG) were recruited from the database of the nation-wide chest pain registry. MetS was defined according to the criteria of the International Diabetes Federation. OCAD was defined as ≥50% stenosis of the left main coronary artery and/or ≥70% stenosis of any other coronary arteries. Women were older than men (65 vs. 59 years, < 0.001). OCAD (32.0% vs. 30.9%) and MetS (27.8% vs. 27.9%) prevalence rates were similar in both sexes ( > 0.05). The presence of MetS was associated with higher prevalence of OCAD in women (24.5% vs. 47.3%, < 0.001), but not in men (31.0% vs. 34.3%, = 0.487). The linear association between the number of components meeting MetS criteria and OCAD prevalence was significant in both sexes ( < 0.001 for each), but it was stronger in women than in men (Chi-square value: 81.9 vs. 14.8, < 0.001). In a multivariable model, the presence of MetS was independently associated with OCAD in women even after controlling for potential confounders (odds ratio, 1.92; 95% confidence interval, 1.31-2.81; = 0.001). In patients with chest pain undergoing invasive CAG, the association between the number of components meeting MetS criteria and OCAD prevalence was stronger in women than in men.
代谢综合征（MetS）对阻塞性冠状动脉疾病（OCAD）的性别影响尚未得到充分评估。本研究共纳入 1156 名因胸痛接受有创冠状动脉造影（CAG）的患者（62 岁，58%为女性），这些患者均来自全国胸痛注册数据库。MetS 根据国际糖尿病联合会的标准定义。OCAD 定义为左主干冠状动脉≥50%狭窄和/或任何其他冠状动脉≥70%狭窄。女性比男性年龄更大（65 岁比 59 岁，<0.001）。两种性别之间 OCAD（32.0%比 30.9%）和 MetS（27.8%比 27.9%）的患病率相似（>0.05）。在女性中，存在 MetS 与 OCAD 的患病率较高相关（24.5%比 47.3%，<0.001），但在男性中则无相关性（31.0%比 34.3%，=0.487）。在两种性别中，符合 MetS 标准的成分数量与 OCAD 患病率之间的线性关联均具有统计学意义（<0.001），但在女性中比在男性中更强（卡方值：81.9 比 14.8，<0.001）。在多变量模型中，即使在控制了潜在混杂因素后，MetS 的存在与女性的 OCAD 独立相关（优势比，1.92；95%置信区间，1.31-2.81；=0.001）。在因胸痛接受有创 CAG 的患者中，符合 MetS 标准的成分数量与 OCAD 患病率之间的关联在女性中比在男性中更强。
