Puig L, Moreno A, Moragas J M
Servicio de Anatomía Patológica, Hospital de "San Pablo", Barcelona.
Med Cutan Ibero Lat Am. 1987;15(6):481-8.
We have applied a battery of murine monoclonal antibodies (R-24, L-101, S-171) to the immunohistological diagnosis of 35 pigmented lesions. The results of our study allow us to conclude that: 1) The monoclonal antibody R-24 is a good marker of normal and neoplastic melanocytes, although some melanomas do not stain with this monoclonal antibody. The application of R-24 may contribute to the pathologic differential diagnosis of melanoma metastases. 2) The association of R-24+ and L-101+ staining is found in melanocytic nevus as well as in melanomas, and do not allow the differential diagnosis between them. 3) Stains with R-24, L-101 and S-171 are simultaneously positive only in melanomas, and with low frequency.
我们应用了一系列鼠单克隆抗体（R - 24、L - 101、S - 171）对35例色素沉着病变进行免疫组织学诊断。我们的研究结果使我们得出以下结论：1）单克隆抗体R - 24是正常和肿瘤性黑素细胞的良好标志物，尽管一些黑色素瘤不能被该单克隆抗体染色。R - 24的应用可能有助于黑色素瘤转移的病理鉴别诊断。2）在黑素细胞痣和黑色素瘤中均发现R - 24 +和L - 101 +染色的关联，且无法用于它们之间的鉴别诊断。3）仅在黑色素瘤中，R - 24、L - 101和S - 171染色同时呈阳性，且频率较低。
