School of Chemistry and Chemical Engineering, YanTai University, Yantai, 264005, Shandong, P. R. China.
Org Biomol Chem. 2020 Dec 28;18(48):9762-9774. doi: 10.1039/d0ob02168g. Epub 2020 Nov 25.
In recent years, considerable attention has been devoted to the exploration of novel synthetic methods for fluoro-lactams due to their significant biological and pharmaceutical activities. This review summarizes recently established strategies for synthesizing fluorine-substituted lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams. Additionally, the reaction scopes, limitations, and mechanisms are discussed.
近年来，由于氟代内酰胺具有重要的生物和药物活性，因此人们对其新型合成方法进行了大量研究。本综述总结了近年来合成氟取代内酰胺的策略，包括氟代β-内酰胺、氟代γ-内酰胺和氟代δ-内酰胺。此外，还讨论了反应的范围、限制和机制。
