The Graduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Korea.
Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Pusan, 49112, Korea.
Arch Pharm Res. 2020 Dec;43(12):1230-1258. doi: 10.1007/s12272-020-01288-1. Epub 2020 Nov 25.
Actinomycetes are an important source for bioactive secondary metabolites. Among them, the genus Salinispora is one of the first salt obligatory marine species worldwide and is typically found in various types of substrates in tropical and subtropical marine environments including sediments and marine organisms. This genus produces a wide range of chemical scaffolds and bioactive compounds such as lomaiviticins, cyclomarins, rifamycins, salinaphthoquinones, and salinosporamides. This review arranged Salinispora derived secondary metabolites according to the three species that comprise the genus. Moreover, muta- and semi-synthesis analogs derived from salinosporamide were also described in this review.
放线菌是生物活性次生代谢物的重要来源。其中，盐孢菌属是世界上最早的盐专性海洋物种之一，通常存在于热带和亚热带海洋环境中的各种基质中，包括沉积物和海洋生物。该属产生广泛的化学支架和生物活性化合物，如洛马维丁、环马霉素、利福霉素、盐萘醌和盐孢菌素。本综述根据构成该属的三个物种排列了盐孢菌来源的次生代谢物。此外，本文还描述了源自盐孢菌素的突变体和半合成类似物。
