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土耳其伊兹密尔大学队列研究:使用法匹拉韦治疗 SARS-CoV-2 肺炎:初步结果。

Treatment of SARS-CoV-2 pneumonia with favipiravir: early results from the Ege University cohort, Turkey.

机构信息

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, İzmir, Turkey

Department of Chest Diseases, Faculty of Medicine, Ege University, İzmir, Turkey

出版信息

Turk J Med Sci. 2021 Jun 28;51(3):912-920. doi: 10.3906/sag-2008-33.

Abstract

BACKGROUND/AIM: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia.

MATERIALS AND METHODS

This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia.

RESULTS

Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) when this paper was written.

CONCLUSION

This study provides relevant information for the treatment of COVID-19, suggesting that favipiravir was associated with significant clinical and laboratory improvements in the majority of the patients, is a safe drug with no serious side effects and would merit further investigation.

摘要

背景/目的:本文旨在分享土耳其伊兹密尔大学在使用法匹拉韦治疗严重 SARS-CoV-2 肺炎方面的经验。

材料与方法

本回顾性描述性研究纳入了患有或发展为重症肺炎的 COVID-19 患者。

结果

共有 40 名完成了完整疗程(至少 5 天)的法匹拉韦治疗的患者纳入本研究。基线时,30 名(75%)患者需要治疗呼吸窘迫。33 名患者(82.5%)完全康复出院,6 名患者(15%)死亡,1 名患者(2.5%)在本文撰写时仍在重症监护病房(ICU)。

结论

本研究为 COVID-19 的治疗提供了相关信息,提示法匹拉韦可使大多数患者的临床和实验室指标显著改善,是一种安全的药物,无严重副作用,值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/8283495/8dccb70ebb25/turkjmedsci-51-912-fig001.jpg

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