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细胞因子风暴与 COVID-19 的免疫调节治疗：氯喹和抗 IL-6 单克隆抗体的作用。

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies.

机构信息

Department of Pharmacy, Beijing Hospital, National Centre of Gerontology, Beijing, P.R. China; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.

出版信息

Int J Antimicrob Agents. 2020 Jun;55(6):105982. doi: 10.1016/j.ijantimicag.2020.105982. Epub 2020 Apr 16.

DOI:10.1016/j.ijantimicag.2020.105982
PMID:32305588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7161506/
Abstract

• Discussion of the role of immunomodulatory agents to reduce the cytokine storm in severe cases of COVID-19. • Potential immunomodulatory agents currently used in the treatment of COVID-19 (chloroquine, hydroxychloroquine and tocilizumab) are discussed. • Other immunomodulatory agents with good safety profiles may be considered for use in combination with antiviral drugs for the treatment of severe or critical cases of COVID-19.

摘要

• 探讨免疫调节剂在降低 COVID-19 重症患者细胞因子风暴中的作用。• 讨论目前用于治疗 COVID-19 的潜在免疫调节剂（氯喹、羟氯喹和托珠单抗）。• 对于重症或危重症 COVID-19 患者，可考虑联合抗病毒药物使用其他具有良好安全性特征的免疫调节剂。

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Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975. doi: 10.1073/pnas.2005615117. Epub 2020 Apr 29.
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Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19).COVID-19 患者的皮质类固醇治疗。
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