Department of Pathology, Xiangya Hospital, Central South University, 87 Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, China.
Virchows Arch. 2022 Jul;481(1):101-110. doi: 10.1007/s00428-022-03320-9. Epub 2022 Apr 9.
Interdigitating dendritic cell sarcoma (IDCS) is a rare, highly malignant tumor with a poor prognosis, and current knowledge of this tumor is limited. It is reported that lymph nodes are the primary localization sites. However, in recent years, many primary IDCS have also been reported in the extra-nodal sites, which undoubtedly increases the difficulty of diagnosis. There are very few reports that systematically analyze the clinicopathologic features of IDCS. Here we described two cases of extra-nodal IDCS and reviewed the literature of 44 other published cases of extra-nodal IDCS. Thus, the clinical symptoms, pathological diagnosis, and therapeutic effects of 46 cases of extra-nodal IDCS were summarized in detail. Considering the paucity of available data with regard to IDCS, a thorough and detailed summary would help to better diagnose and treat this neoplasm.
指状突树突细胞肉瘤（IDCS）是一种罕见的、高度恶性肿瘤，预后不良，目前对这种肿瘤的了解有限。据报道，淋巴结是主要的定位部位。然而，近年来，许多原发于结外部位的 IDCS 也有报道，这无疑增加了诊断的难度。很少有系统分析 IDCS 的临床病理特征的报道。在此，我们描述了两例结外 IDCS，并复习了 44 例其他已发表的结外 IDCS 病例的文献。因此，详细总结了 46 例结外 IDCS 的临床症状、病理诊断和治疗效果。鉴于 IDCS 可用数据有限，全面详细的总结将有助于更好地诊断和治疗这种肿瘤。
