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R6 - 5的TraT蛋白疏水区域中的氨基酸改变增加了肠道细菌的外膜通透性。

Amino acid alterations in a hydrophobic region of the TraT protein of R6-5 increase the outer membrane permeability of enteric bacteria.

作者信息

Sukupolvi S, O'Connor D

机构信息

National Public Health Institute, Helsinki, Finland.

出版信息

Mol Gen Genet. 1987 Nov;210(1):178-80. doi: 10.1007/BF00337776.

DOI:10.1007/BF00337776
PMID:3323837
Abstract

Two insertion mutations, each introducing a new negatively charged amino acid residue into a hydrophobic region of the TraT protein coded by the F-like plasmid R6-5 caused significant alterations in outer membrane permeability of Escherichia coli and Salmonella typhimurium, so that strains carrying plasmids with either of these mutations became sensitive to hydrophobic antibiotics.

摘要

两个插入突变，每个突变都将一个新的带负电荷的氨基酸残基引入由F类质粒R6 - 5编码的TraT蛋白的疏水区域，这导致大肠杆菌和鼠伤寒沙门氏菌的外膜通透性发生显著改变，使得携带这两种突变之一的质粒的菌株对疏水性抗生素变得敏感。

相似文献

1
Amino acid alterations in a hydrophobic region of the TraT protein of R6-5 increase the outer membrane permeability of enteric bacteria.R6 - 5的TraT蛋白疏水区域中的氨基酸改变增加了肠道细菌的外膜通透性。
Mol Gen Genet. 1987 Nov;210(1):178-80. doi: 10.1007/BF00337776.
2
Characterization of the traT gene and mutants that increase outer membrane permeability from the Salmonella typhimurium virulence plasmid.
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J Gen Microbiol. 1986 Aug;132(8):2079-85. doi: 10.1099/00221287-132-8-2079.
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The role of the pilus in recipient cell recognition during bacterial conjugation mediated by F-like plasmids.菌毛在由F类质粒介导的细菌接合过程中对受体细胞识别的作用。
Mol Microbiol. 1994 Sep;13(6):939-53. doi: 10.1111/j.1365-2958.1994.tb00486.x.
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Surface exclusion specificity of the TraT lipoprotein is determined by single alterations in a five-amino-acid region of the protein.TraT脂蛋白的表面排斥特异性由该蛋白五氨基酸区域的单个改变所决定。
Mol Microbiol. 1992 Oct;6(19):2825-32. doi: 10.1111/j.1365-2958.1992.tb01462.x.
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TraT lipoprotein, a plasmid-specified mediator of interactions between gram-negative bacteria and their environment.TraT脂蛋白，一种由质粒指定的革兰氏阴性菌与其环境之间相互作用的介质。
Microbiol Rev. 1990 Dec;54(4):331-41. doi: 10.1128/mr.54.4.331-341.1990.
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Salmonella typhimurium and Escherichia coli mutants with increased outer membrane permeability to hydrophobic compounds.对疏水性化合物外膜通透性增加的鼠伤寒沙门氏菌和大肠杆菌突变体。
Biochim Biophys Acta. 1989 Dec 6;988(3):377-87. doi: 10.1016/0304-4157(89)90011-7.
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Outer membrane permeability of Escherichia coli K12: isolation, cloning and mapping of suppressors of a defined antibiotic-hypersensitive mutant.大肠杆菌K12的外膜通透性：一种特定抗生素超敏突变体抑制子的分离、克隆与定位
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Genes on the 90-kilobase plasmid of Salmonella typhimurium confer low-affinity cobalamin transport: relationship to fimbria biosynthesis genes.鼠伤寒沙门氏菌90千碱基质粒上的基因赋予低亲和力钴胺素转运功能：与菌毛生物合成基因的关系。
J Bacteriol. 1990 Nov;172(11):6217-22. doi: 10.1128/jb.172.11.6217-6222.1990.

引用本文的文献

1
Linkage map of Salmonella typhimurium, edition VII.鼠伤寒沙门氏菌连锁图谱，第七版。
Microbiol Rev. 1988 Dec;52(4):485-532. doi: 10.1128/mr.52.4.485-532.1988.
2
TraT lipoprotein, a plasmid-specified mediator of interactions between gram-negative bacteria and their environment.TraT脂蛋白，一种由质粒指定的革兰氏阴性菌与其环境之间相互作用的介质。
Microbiol Rev. 1990 Dec;54(4):331-41. doi: 10.1128/mr.54.4.331-341.1990.
3
Outer membrane permeability of Escherichia coli K12: isolation, cloning and mapping of suppressors of a defined antibiotic-hypersensitive mutant.

本文引用的文献

1
A simple method for displaying the hydropathic character of a protein.一种展示蛋白质亲水性特征的简单方法。
J Mol Biol. 1982 May 5;157(1):105-32. doi: 10.1016/0022-2836(82)90515-0.
2
Plasmid-determined resistance to serum bactericidal activity: a major outer membrane protein, the traT gene product, is responsible for plasmid-specified serum resistance in Escherichia coli.质粒介导的对血清杀菌活性的抗性：一种主要外膜蛋白，即traT基因产物，负责大肠杆菌中质粒特异性的血清抗性。
Infect Immun. 1980 May;28(2):359-67. doi: 10.1128/iai.28.2.359-367.1980.
3
Lipopolysaccharide heterogeneity in Salmonella typhimurium analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis.
大肠杆菌K12的外膜通透性：一种特定抗生素超敏突变体抑制子的分离、克隆与定位
Mol Gen Genet. 1991 Oct;229(3):421-7. doi: 10.1007/BF00267465.
通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳分析鼠伤寒沙门氏菌中的脂多糖异质性。
Eur J Biochem. 1980;107(1):137-43. doi: 10.1111/j.1432-1033.1980.tb04634.x.
4
Outer membrane of Escherichia coli: properties of the F sex factor traT protein which is involved in surface exclusion.大肠杆菌外膜：参与表面排斥的F性因子traT蛋白的特性
J Bacteriol. 1980 Apr;142(1):285-94. doi: 10.1128/jb.142.1.285-294.1980.
5
A plasmid-encoded outer membrane protein, TraT, enhances resistance of Escherichia coli to phagocytosis.一种质粒编码的外膜蛋白TraT可增强大肠杆菌对吞噬作用的抗性。
Infect Immun. 1984 Dec;46(3):740-6. doi: 10.1128/iai.46.3.740-746.1984.
6
New Salmonella typhimurium mutants with altered outer membrane permeability.具有改变的外膜通透性的新型鼠伤寒沙门氏菌突变体。
J Bacteriol. 1984 Aug;159(2):704-12. doi: 10.1128/jb.159.2.704-712.1984.
7
Inducible high level synthesis of mature human fibroblast interferon in Escherichia coli.在大肠杆菌中诱导高水平合成成熟的人成纤维细胞干扰素。
Nucleic Acids Res. 1983 Jul 25;11(14):4677-88. doi: 10.1093/nar/11.14.4677.
8
Nucleotide sequence analysis of the complement resistance gene from plasmid R100.质粒R100补体抗性基因的核苷酸序列分析
J Bacteriol. 1982 Aug;151(2):819-27. doi: 10.1128/jb.151.2.819-827.1982.
9
Association of adhesive, invasive, and virulent phenotypes of Salmonella typhimurium with autonomous 60-megadalton plasmids.鼠伤寒沙门氏菌的黏附、侵袭和毒力表型与自主的60兆道尔顿质粒的关联。
Infect Immun. 1982 Nov;38(2):476-86. doi: 10.1128/iai.38.2.476-486.1982.
10
Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid.质粒脱氧核糖核酸对鼠伤寒沙门氏菌的转化
J Bacteriol. 1974 Sep;119(3):1072-4. doi: 10.1128/jb.119.3.1072-1074.1974.