Cheng B, Fu X B
Department of Burns and Plastic Surgery, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China.
Research Center for Wound Repair and Regeneration, Medical Innovation Research Department, the PLA General Hospital, Beijing 100048, China.
Zhonghua Shao Shang Za Zhi. 2020 Nov 20;36(11):1003-1008. doi: 10.3760/cma.j.cn501120-20201009-00429.
With gradually in-depth understanding of wound healing mechanism, the concept and composition of wound microenvironment have been improved and clarified. In the process of wound healing, the external microenvironment and internal microenvironment are both relatively independent and interact with each other, and are always in dynamic change. It is necessary to understand the changing rules and characteristics of wound healing microenvironment from multiple dimensions, such as space and time, so that the process of wound healing can be purposefully regulated and controlled depending on actual circumstance. It helps the adoption of reasonable regenerative medicine technology at the proper time window to realize perfect repair and regeneration after skin and soft tissue injury in the true sense.
随着对伤口愈合机制的理解逐渐深入，伤口微环境的概念和组成得到了完善和明确。在伤口愈合过程中，外部微环境和内部微环境既相对独立又相互作用，且始终处于动态变化之中。有必要从空间和时间等多个维度了解伤口愈合微环境的变化规律和特点，以便根据实际情况有目的地调控伤口愈合过程。这有助于在适当的时间窗采用合理的再生医学技术，真正实现皮肤和软组织损伤后的完美修复与再生。
