成人皮肤的伤口愈合：追求完美的再生。

Wound healing in adult skin: aiming for perfect regeneration.

机构信息

UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

Int J Dermatol. 2011 Sep;50(9):1058-66. doi: 10.1111/j.1365-4632.2011.04940.x.

DOI:10.1111/j.1365-4632.2011.04940.x

Abstract

Wound healing in adult skin, a complex process involving many cell types and processes such as epidermal, fibroblastic, and endothelial cell proliferation, cell migration, matrix synthesis, and wound contraction, almost invariably results in scar tissue formation and wound induration. Unlike in adult skin, wound healing in embryos involves repair processes that result in the essentially perfect regeneration of damaged tissue. This paper discusses key mechanisms that lead to scar tissue formation in adult human skin and treatment modalities, including curcumin gel, that may result in essentially perfect skin regeneration following surgical procedures.

摘要

成人皮肤的伤口愈合是一个复杂的过程，涉及许多细胞类型和过程，如表皮、成纤维细胞和内皮细胞的增殖、细胞迁移、基质合成和伤口收缩，几乎总是导致疤痕组织形成和伤口硬结。与成人皮肤不同，胚胎中的伤口愈合涉及修复过程，导致受损组织的基本完美再生。本文讨论了导致成人皮肤形成疤痕组织的关键机制和治疗方法，包括姜黄素凝胶，它可能导致手术后皮肤的基本完美再生。