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同期活体供肾移植与腹腔镜下原位肾切除术:疑似肾癌的肾移植候选者的一种处理方法。

Simultaneous Living Donor Kidney Transplant and Laparoscopic Native Nephrectomy: An Approach to Kidney Transplant Candidates with Suspected Renal-Cell Carcinoma.

机构信息

Department of Surgery, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York, USA.

出版信息

J Endourol. 2021 Jul;35(7):1001-1005. doi: 10.1089/end.2020.0841. Epub 2020 Dec 31.

DOI:10.1089/end.2020.0841
PMID:33238756
Abstract

Kidney transplant candidates are occasionally found during the pre-transplant evaluation to have a suspicious mass in a native kidney. Further work-up and management of such a mass may delay transplantation for several months, which may create logistic barriers to transplant, particularly if there are timing constraints of the donor. In this study, we report our experience with simultaneous living donor kidney transplant and laparoscopic native nephrectomy, where the indication for nephrectomy was a suspicious lesion. We performed a retrospective review of patients who underwent simultaneous kidney transplant and native nephrectomy using prospectively collected data. We analyzed relevant patient characteristics, surgical details, pathologic results, and long-term follow-up. We identified 16 patients who underwent simultaneous living donor kidney transplantation and laparoscopic native nephrectomy at our institution between 2013 and 2018. Ten (62.5%) patients were found to have renal-cell carcinoma (RCC) on the final pathology. No patients had recurrent RCC, at a median follow-up of 4 years. For patients who are planning to undergo a living donor kidney transplant and are found to have a small mass that is suspicious for RCC, a simultaneous living donor kidney transplant and laparoscopic native nephrectomy is a possible approach in selected patients.

摘要

肾移植候选人在移植前评估中偶尔会发现其原肾有可疑肿块。进一步的检查和处理这种肿块可能会使移植延迟数月,这可能会给移植带来后勤障碍,特别是如果供体存在时间限制的话。在这项研究中,我们报告了我们同时进行活体供肾移植和腹腔镜下原肾切除术的经验,原肾切除术的指征是可疑病变。我们对 2013 年至 2018 年间在我们机构接受同时进行活体供肾移植和腹腔镜下原肾切除术的患者进行了回顾性分析,使用前瞻性收集的数据。我们分析了相关的患者特征、手术细节、病理结果和长期随访。我们确定了 16 名患者在我们机构接受了同时进行的活体供肾移植和腹腔镜下原肾切除术。最终病理检查发现 10 名(62.5%)患者患有肾细胞癌(RCC)。在中位数为 4 年的随访中,没有患者出现 RCC 复发。对于计划接受活体供肾移植且发现疑似 RCC 的小肿块的患者,对于选择的患者来说,同时进行活体供肾移植和腹腔镜下原肾切除术是一种可行的方法。

相似文献

1
Simultaneous Living Donor Kidney Transplant and Laparoscopic Native Nephrectomy: An Approach to Kidney Transplant Candidates with Suspected Renal-Cell Carcinoma.同期活体供肾移植与腹腔镜下原位肾切除术:疑似肾癌的肾移植候选者的一种处理方法。
J Endourol. 2021 Jul;35(7):1001-1005. doi: 10.1089/end.2020.0841. Epub 2020 Dec 31.
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Living donor renal transplantation with incidental renal cell carcinoma from donor allograft.活体供肾肾移植术中供者移植肾合并肾细胞癌
Transpl Int. 2015 Sep;28(9):1126-30. doi: 10.1111/tri.12594. Epub 2015 May 7.
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Native nephrectomy for renal cell carcinoma in transplant recipients.移植受者的肾细胞癌的肾切除术。
Transplantation. 2011 Jun 27;91(12):1376-9. doi: 10.1097/TP.0b013e31821ab97a.
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Simultaneous laparoendoscopic single-site radical nephrectomy for native kidney and open nonischemic partial nephrectomy to treat concomitant renal cell carcinomas in native and transplant kidneys and to preserve allograft function.同期腹腔镜单部位肾根治性切除术治疗原肾和开放非缺血性部分肾切除术治疗原肾和移植肾的同时性肾细胞癌,并保留移植物功能。
Urology. 2012 Jan;79(1):139-44. doi: 10.1016/j.urology.2011.09.015. Epub 2011 Nov 4.
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Native nephrectomy in transplant patients with autosomal dominant polycystic kidney disease.常染色体显性遗传性多囊肾病移植患者的自体肾切除术
Ann R Coll Surg Engl. 2011 Jul;93(5):391-5. doi: 10.1308/003588411X582690.
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[Laparoscopic living donor nephrectomy for kidney transplantation].[用于肾移植的腹腔镜活体供肾切除术]
Urologiia. 2016 Apr(2):92-95.
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Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature.中国肾移植受者原发性肾脏肾细胞癌:12 例报告及文献复习。
Int Urol Nephrol. 2011 Sep;43(3):675-80. doi: 10.1007/s11255-011-9912-2. Epub 2011 Mar 10.
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The economic impact of laparoscopic living-donor nephrectomy on kidney transplantation.腹腔镜活体供肾肾切除术对肾移植的经济影响。
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Living-donor renal transplantation of grafts with incidental renal masses after ex-vivo partial nephrectomy.体外部分肾切除术后偶然发现的肾肿块供体的活体肾移植。
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Management of renal masses in transplant allografts at an Australian kidney-pancreas transplant unit.澳大利亚肝肾移植单位移植肾移植物中肾肿瘤的处理。
Transplantation. 2014 Mar 27;97(6):654-9. doi: 10.1097/01.TP.0000437333.38786.fd.

引用本文的文献

1
Recurrence of renal cell carcinoma after simultaneous radical nephrectomy and cadaver renal transplant.同期根治性肾切除术与尸体肾移植术后肾细胞癌复发
IJU Case Rep. 2022 Jun 24;5(5):397-400. doi: 10.1002/iju5.12499. eCollection 2022 Sep.
2
Small renal masses in kidney transplantation: Overview of clinical impact and management in donors and recipients.肾移植中的小肾肿块:供体和受体的临床影响及管理概述
Asian J Urol. 2022 Jul;9(3):208-214. doi: 10.1016/j.ajur.2022.06.001. Epub 2022 Jun 10.