：具有良好前景的抗癌生物标志物的生物碱。
Alkaloids of : Anticancer Biomarkers with Promising Outcomes.
机构信息
Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Curr Pharm Des. 2021;27(2):185-196. doi: 10.2174/1381612826666201125103941.
BACKGROUND
Cancer is a serious and growing global health issue worldwide. In the cancerous cells, the normal cell cycle has been disrupted via a series of irreversible changes. Recently, the investigations on herbal medicine and clarifying the phytochemicals potential in treat cancer has been increased. The combination of phytochemicals with conventional cancer treatment approaches can improve outcomes via advancing cell death, restraining cell proliferation and invasion, sensitizing cancerous cells, and promoting the immune system. Therefore, phytochemicals can be introduced as relevant complementary medicaments in cancer therapy. Peganum harmala L. (Zygophyllaceae) as a valuable medicinal herb, possesses various alkaloid ingredient.
OBJECTIVE
Pointing to the importance of new avenues for cancer management and P. harmala convincing effect in this field, this review strived to collect a frame to epitome possible scopes to develop novel medicines in cancer treatment.
METHODS
Keywords "Peganum harmala" and cancer, or chemotherapy, or anti-neoplasm were searched through the "Scopus" database up to 29th of February 2020. Papers linking to agriculture, chemistry, environmental, and genetics sciences were omitted and, papers centered on cancer were selected.
RESULTS AND DISCUSSION
In the current study, 42 related papers to cancer treatment and 22 papers on alkaloid bioactive components are collected from 72 papers. The β-carboline alkaloids derived from P. harmala, especially harmine, demonstrate notable anticancer properties by targeting apoptosis, autophagy, abnormal cell proliferation, angiogenesis, metastasis, and cytotoxicity. Based on the collected information, P. harmala holds significant anticancer activity. Considering the mechanism of the various anticancer drugs and their acting similarity to P. harmala, the alkaloids derived from this herb, particularly harmine, can introduce as a novel anticancer medicine solely or in adjuvant cancer therapy.
背景
癌症是全球范围内一个严重且日益严重的全球健康问题。在癌细胞中，正常的细胞周期通过一系列不可逆转的变化而被打乱。最近，对草药的研究以及阐明植物化学物质治疗癌症的潜力的研究有所增加。通过促进细胞死亡、抑制细胞增殖和侵袭、使癌细胞敏感以及促进免疫系统，植物化学物质与常规癌症治疗方法的结合可以改善治疗效果。因此，植物化学物质可以作为癌症治疗中的相关辅助药物。骆驼蓬（Peganum harmala L.）（蒺藜科）作为一种有价值的药用植物，具有各种生物碱成分。
目的
鉴于癌症管理的新途径的重要性以及骆驼蓬在这一领域的令人信服的效果，本综述旨在收集一个框架，以概述在癌症治疗中开发新型药物的可能范围。
方法
通过“Scopus”数据库，于 2020 年 2 月 29 日之前搜索了关键词“Peganum harmala”和癌症、化疗或抗肿瘤，并排除了与农业、化学、环境和遗传学相关的论文，只选择了以癌症为中心的论文。
结果与讨论
在本研究中，从 72 篇论文中收集到 42 篇与癌症治疗相关的论文和 22 篇关于生物碱生物活性成分的论文。骆驼蓬中提取的β-咔啉生物碱，特别是骆驼蓬碱，通过靶向细胞凋亡、自噬、异常细胞增殖、血管生成、转移和细胞毒性，显示出显著的抗癌特性。根据收集到的信息，骆驼蓬具有显著的抗癌活性。考虑到各种抗癌药物的作用机制及其与骆驼蓬的相似性，这种草药衍生的生物碱，特别是骆驼蓬碱，可以单独或作为辅助癌症治疗的一种新型抗癌药物。
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