Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Croatia.
Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Croatia.
Brain Dev. 2021 Mar;43(3):363-371. doi: 10.1016/j.braindev.2020.11.002. Epub 2020 Nov 22.
To explore the relationships between transient structural brain patterns on MRI at preterm and at term-equivalent age (TEA) as a predictor of general movements (GMs) and motor development at 1-year corrected age (CA) in very preterm infants.
In this prospective study, 30 very preterm infants (median = 28wks; 16 males) had structural magnetic resonance imaging (MRI) at preterm (median = 31wks + 6d) and at TEA (median = 40wks) and neuromotor assessments. The quality of GMs was assessed by Prechtl's general movements assessment and a detailed analysis of the motor repertoire was performed by calculating a motor optimality score (MOS), both at term age and at 3 months post-term. Motor development at 1-year CA was evaluated with the Infant Motor Profile (IMP). Associations between qualitative MRI findings and neuromotor scores were investigated.
Abnormal GMs and low motor performance at 1-year CA were associated with the poor visibility of transient structural pattern, that is with sagittal strata.
Transient structural MRI pattern, sagittal strata, at preterm age is related to the quality of GMs and later motor development in preterm infants. This transient fetal brain compartment may be considered as a component of neurobiological basis for early neuromotor behavior, as expressed by GMs.
探讨早产儿和胎龄相当时间（TEA）时 MRI 上短暂性脑结构模式与全身运动（GMs）和极早产儿 1 年校正年龄（CA）时运动发育之间的关系。
在这项前瞻性研究中，30 名极早产儿（中位数=28 周；16 名男性）在早产儿（中位数=31 周+6 天）和 TEA（中位数=40 周）时进行了结构磁共振成像（MRI）检查，并进行了神经运动评估。GMs 的质量通过 Prechtl 的全身运动评估进行评估，并且在足月时和足月后 3 个月通过计算运动最佳得分（MOS）来对运动模式进行详细分析。1 年 CA 时的运动发育通过婴儿运动概况（IMP）进行评估。研究了定性 MRI 结果与神经运动评分之间的关联。
GMs 异常和 1 年 CA 时运动能力低下与短暂性结构模式（即矢状层）的可视性差有关。
早产儿时的短暂性脑结构 MRI 模式、矢状层与早产儿 GMs 和后期运动发育有关。这种短暂的胎儿脑区室可能被认为是 GM 表达的早期神经运动行为的神经生物学基础的组成部分。
