Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California 94305.
J Neurosci. 2021 Feb 3;41(5):855-865. doi: 10.1523/JNEUROSCI.1650-20.2020. Epub 2020 Nov 25.
Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.
慢性疼痛包括多种疾病，如腰痛、关节炎、持续性手术后疼痛、纤维肌痛和神经病理性疼痛障碍等，其发病率很高，但治疗效果仍然不佳。尽管现在已经认识到免疫细胞、神经胶质细胞和神经元之间的信号传递对于慢性疼痛的发生和维持是必不可少的，但绝大多数治疗方法仅针对神经元。本综述强调了在慢性疼痛的啮齿动物模型中，对基本神经免疫信号机制和新治疗靶点的理解方面的最新进展。我们还进一步讨论了新的技术发展，以研究、诊断和量化慢性疼痛患者人群中神经免疫的贡献。
