Khammesri Siripat, Mathura Yaoprapa, Boonprasert Khajohnpat, Ampasavate Chadarat, Hongwiset Darunee, Brown Janine L, Thitaram Chatchote
Graduate Program in Veterinary Science, Faculty of Veterinary Medicine, Chiang Mai University, 155, Mae Hia, Muang, Chiang Mai, 50100, Thailand.
Center of Elephant and Wildlife Research, Faculty of Veterinary Medicine, Chiang Mai University, 155, Mae Hia, Muang, Chiang Mai, 50100, Thailand.
J Vet Med Sci. 2021 Jan 14;83(1):125-129. doi: 10.1292/jvms.20-0375. Epub 2020 Nov 25.
Elephant endotheliotropic herpesvirus (EEHV) is a major cause of death in Asian elephant (Elephas maximus) calves. A 2-year, 11-month-old female, captive Asian elephant presented with facial edema and a mild fever. Blood samples were collected and showed EEHV1A positivity with a high viral load by real time PCR. Heterophil toxicity also was reported for the first time in this case. The calf was treated orally with acyclovir, 45 mg/kg tid for 28 days, which reduced the EEHV1A viral load to undetectable levels within 9 days and the calf survived. A successful outcome with oral acyclovir administration provides another and affordable option to treat EEHV hemorrhagic disease in Asian elephants, and one that is easier to administer in untrained calves.
大象内皮嗜性疱疹病毒（EEHV）是亚洲象（Elephas maximus）幼崽死亡的主要原因。一头2岁11个月大的圈养亚洲象雌性幼崽出现面部水肿和低热。采集血样，通过实时PCR检测显示EEHV1A呈阳性且病毒载量高。该病例还首次报告了异嗜性毒性。给这头幼象口服阿昔洛韦进行治疗，剂量为45毫克/千克，每日3次，持续28天，这使得EEHV1A病毒载量在9天内降至检测不到的水平，幼象存活下来。口服阿昔洛韦治疗取得成功，为治疗亚洲象的EEHV出血性疾病提供了另一种经济实惠的选择，而且在未经训练的幼象中更易于给药。
