新冠肺炎“康复”患者的 SARS-CoV-2 RNA 复测阳性：持续性、采样问题还是再感染？
Retest positive for SARS-CoV-2 RNA of "recovered" patients with COVID-19: Persistence, sampling issues, or re-infection?
机构信息
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Departments of Pathology and Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia.
出版信息
J Med Virol. 2020 Nov;92(11):2263-2265. doi: 10.1002/jmv.26114. Epub 2020 Jun 9.
Abstract
"Retest Positive" for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) from "recovered" coronavirus disease-19 (COVID-19) has been reported and raised several important questions for this novel coronavirus and COVID-19 disease. In this commentary, we discussed several questions: (a) Can SARS-CoV-2 re-infect the individuals who recovered from COVID-19? This question is also associated with other questions: whether or not SARS-CoV-2 infection induces protective reaction or neutralized antibody? Will SARS-CoV-2 vaccines work? (b) Why could some recovered patients with COVID-19 be re-tested positive for SARS-CoV-2 RNA? (c) Are some recovered pwith atients COVID-19 with re-testing positive for SARS-CoV-2 RNA infectious? and (d) How should the COVID-19 patients with retest positive for SARS-CoV-2 be managed?
摘要
从“康复”的 2019 冠状病毒病（COVID-19）中检测到严重急性呼吸综合征相关冠状病毒-2（SARS-CoV-2）的“再检测阳性”，这为这种新型冠状病毒和 COVID-19 疾病提出了几个重要问题。在这篇评论中，我们讨论了几个问题：（a）SARS-CoV-2 是否会再次感染从 COVID-19 中康复的个体？这个问题也与其他问题相关：SARS-CoV-2 感染是否会引起保护性反应或中和抗体？SARS-CoV-2 疫苗是否有效？（b）为什么一些 COVID-19 康复患者的 SARS-CoV-2 RNA 会再次检测呈阳性？（c）一些康复的 COVID-19 患者再次检测出 SARS-CoV-2 RNA 阳性是否具有传染性？和（d）如何管理 SARS-CoV-2 再检测阳性的 COVID-19 患者？
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