Mousavi Soraya, Bereswill Stefan, Heimesaat Markus M
Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Eur J Microbiol Immunol (Bp). 2019 Aug 16;9(3):73-79. doi: 10.1556/1886.2019.00016. eCollection 2019 Oct 3.
Humans have lost their vitamin C-synthesizing capacities during evolution. Therefore, the uptake of this essential compound from external sources is mandatory in order to prevent vitamin C-deficient conditions resulting in severe morbidities such as scurvy. The potent antioxidant, immunomodulatory, and antiinfectious effects of vitamin C are known since the 1930s. We here (i) review the impact of vitamin C on innate and adaptive immune functions, (ii) provide an overview of its antimicrobial, antibacterial, antiviral, antiparasitic, and antifungal properties, and finally, (iii) discuss vitamin C as an adjunct treatment option for the combat of human infections by bacteria, particularly by emerging multidrug-resistant species.
在进化过程中，人类失去了合成维生素C的能力。因此，必须从外部来源摄取这种必需化合物，以预防因维生素C缺乏而导致的严重疾病，如坏血病。自20世纪30年代以来，维生素C的强大抗氧化、免疫调节和抗感染作用就已为人所知。我们在此（i）回顾维生素C对固有免疫和适应性免疫功能的影响，（ii）概述其抗菌、抗病毒、抗寄生虫和抗真菌特性，最后，（iii）讨论将维生素C作为辅助治疗选项用于对抗人类细菌感染，尤其是对抗新出现的多重耐药菌。
