非透析依赖型慢性肾脏病患者甲状旁腺激素水平与尿镁排泄的相关性

Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease.

作者信息

Carneiro Dias Raimunda Sheyla, José de Araújo Brito Dyego, Milhomem Dos Santos Elisângela, Cadilhe de Oliveira Costa Rayanna, Martins Melo Fontenele Andrea, Viana Hortegal Furtado Elane, Santos Lages Joyce, Miranda Dos Santos Alcione, Freitas Santos Elton Jonh, de Lima Carneiro Érika Cristina Ribeiro, Cruz Diniz Maria Célia, Trindade Barbosa Carla Déa, Costa de Sales Muniz Alessandra, Teixeira da Cunha França Ana Karina, Salgado Filho Natalino, Vianna Araújo Denizar, Bernardo-Filho Mário

机构信息

Center for Prevention of Kidney Diseases, University Hospital of the Federal University of Maranhão, São Luís, MA, Brazil.

Nursing Department, Federal University of Maranhão, São Luís, MA, Brazil.

出版信息

Int J Nephrol Renovasc Dis. 2020 Nov 19;13:341-348. doi: 10.2147/IJNRD.S282106. eCollection 2020.

DOI:10.2147/IJNRD.S282106

PMID:33239901

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7682596/

Abstract

BACKGROUND

Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis dependent CKD.

METHODS

Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg).

RESULTS

The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (>89.5pg/mL), the mean levels of FEMg and ALP were higher (p<0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02-1.23), calcium (OR = 0.45; 95% CI: 0.22-0.90), ALP (OR = 1.02; 95% CI: 1.00-1.03) and eGFR (OR = 0.92; 95% CI: 1.00-1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH.

CONCLUSION

In patients with non-dialysis dependent CKD, FEMg and ALP were some variables that remained associated with PTH.

摘要

背景

大多数慢性肾脏病（CKD）患者会出现矿物质代谢紊乱。本研究旨在探讨非透析依赖型CKD患者甲状旁腺激素（PTH）水平与尿镁排泄之间的关系。

方法

横断面研究。测定血样中的肌酐、镁、钙、磷、甲状旁腺激素（PTH）、25-羟基维生素D [25(OH)D]和碱性磷酸酶（ALP）浓度。通过每日总排泄量和排泄分数（FEMg）评估尿镁水平。

结果

该研究评估了163例患者，平均年龄为60.7±11.7岁，51.0%为男性。在PTH最高四分位数（>89.5pg/mL）中，FEMg和ALP的平均水平较高（p<0.05）。在未校正的回归分析中，以下变量与血清PTH水平相关：FEMg（比值比（OR）=1.12；95%置信区间（CI）：1.02-1.23）、钙（OR = 0.45；95% CI：0.22-0.90）、ALP（OR = 1.02；95% CI：1.00-1.03）和估算肾小球滤过率（eGFR）（OR = 0.92；95% CI：1.00-1.03）。经过校正分析后，只有FEMg和ALP仍与PTH相关。