University of Novi Sad, Faculty of Medicine, Department of Pathophysiology, Laboratory Medicine, HajdukVeljkova 3, Novi Sad, Serbia, Clinical Center of Vojvodina, Center of Laboratory Medicine, HajdukVeljkova 3 Novi Sad, Serbia.
Clinical Center of Vojvodina, Center of Laboratory Medicine, HajdukVeljkova 3 Novi Sad, Serbia.
Magnes Res. 2018 May 1;31(2):49-57. doi: 10.1684/mrh.2018.0437.
Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far.
We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg). All the CKD patients were divided into two groups according to the values of mGFR (mL/min/1.73m): the first group consisted of those with GFR≥ 60 mL/min/1.73m, whereas the second group included those with GFR< 60 mL/min/1.73m.
FEMg (%) was significantly higher in the group of nondiabetic patients with CKD compared to the healthy subjects [6.3 vs. 5.3 %, P=0.013]. There was also significant difference in the value of FEMg between the first and second groups of CKD patients. Increased FEMg was significantly correlated with all the investigated kidney function parameters, mGFR, ERPF, Cystatin C and albuminuria (r=-0.62; r=-0.60; r=0.77; r=0.39; p<0.01 for all). In multiple regression analyses based on observed parameters of kidney function, only cystatin C was independently and significantly associated with FEMg (multiple correlation coefficients: 0.738, p < 0.001)). Nondiabetic CKD patients with GFR< 60 mL/min/1.73m have increased FEMg above 6.1% with 78.7 % specificity and 83.7% sensitivity.
Highly significant association between kidney functional parameters and FEMg may indicate significance of this parameter in clinical practice.
镁的分数排泄率（FEMg）升高是肾脏损伤的一种非侵入性生物标志物，但迄今为止，其与非糖尿病慢性肾脏病（CKD）患者的肾功能参数的关联尚未得到充分探讨。
我们纳入了 111 名成年非糖尿病 CKD 患者和 30 名对照者。为了准确评估肾功能，我们测量了肾小球滤过率（mGFR）、有效肾血浆流量（ERPF）、胱抑素 C、蛋白尿和镁的分数排泄率（FEMg）。所有 CKD 患者根据 mGFR（mL/min/1.73m）值分为两组：第一组为 GFR≥60 mL/min/1.73m 的患者，第二组为 GFR<60 mL/min/1.73m 的患者。
与健康受试者相比，非糖尿病 CKD 患者的 FEMg（%）明显升高[6.3%比 5.3%，P=0.013]。第一组和第二组 CKD 患者之间的 FEMg 值也存在显著差异。升高的 FEMg 与所有研究的肾功能参数（mGFR、ERPF、胱抑素 C 和蛋白尿）显著相关（r=-0.62；r=-0.60；r=0.77；r=0.39；p<0.01 均）。基于观察到的肾功能参数的多元回归分析中，只有胱抑素 C 与 FEMg 独立且显著相关（多元相关系数：0.738，p<0.001）。GFR<60 mL/min/1.73m 的非糖尿病 CKD 患者的 FEMg 升高超过 6.1%，特异性为 78.7%，敏感性为 83.7%。
肾功能参数与 FEMg 之间存在显著关联，表明该参数在临床实践中的重要性。
