血清25-羟基维生素D浓度与慢性疼痛之间的关联：饮酒习惯的影响。
Association Between Serum 25-Hydroxyvitamin D Concentrations and Chronic Pain: Effects of Drinking Habits.
作者信息
Suzuki Keita, Tsujiguchi Hiromasa, Miyagi Sakae, Thi Thu Nguyen Thao, Hara Akinori, Nakamura Haruki, Shimizu Yukari, Hayashi Koichiro, Yamada Yohei, Minh Nguyen Phat, Tao Yuichi, Kannon Takayuki, Tajima Atsushi, Nakamura Hiroyuki
机构信息
Department of Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.
Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.
出版信息
J Pain Res. 2020 Nov 19;13:2987-2996. doi: 10.2147/JPR.S277979. eCollection 2020.
PURPOSE
Although the explanation for inconsistencies in the reported association between serum 25-hydroxyvitamin D [25(OH)D] levels and chronic pain (CP) has not yet been determined, understanding this discrepancy is necessary for the development of vitamin D supplementation as an effective treatment for CP. The aim of this cross-sectional study was to examine the relationship between 25(OH)D concentrations and CP according to drinking habits in Japanese subjects.
PATIENTS AND METHODS
We distributed invitation letters to 2314 individuals older than 40 years in Shika town, a rural area in Japan, and 724 subjects (386 females; mean age: 63.9 ± 10.4 years) were recruited. CP was defined as persistent pain lasting at least 3 months in any part of the body. Serum concentrations of 25(OH)D, a biomarker of the vitamin D status, were measured using a radioimmunoassay. A serum 25(OH)D level <20 ng/mL was defined as serum 25(OH)D deficiency. Drinking habits were assessed using a self-administered questionnaire. There were three choices, "rarely drink", "sometimes" and "everyday". Respondents who answered "rarely drink" were labelled as non-drinkers and the others as drinkers.
RESULTS
The prevalence of CP was 40.6%. A significant interaction between CP and drinking habits on 25(OH)D concentrations was observed ( = 0.098). A one-way analysis of covariance was performed to compare 25(OH)D concentrations between the subjects with and without CP in each drinking group, and the serum 25(OH)D levels of subjects with CP were significantly lower than those without CP among drinkers ( = 0.007). A logistic regression analysis revealed a correlation between serum 25(OH)D deficiency and CP in drinkers after adjustments for several confounding factors (odds ratio: 0.499; 95% confidence interval: 0.268 - 0.927; = 0.028).
CONCLUSION
The present results suggest that low serum 25(OH)D concentrations are associated with the development of CP in drinkers.
目的
尽管血清25-羟基维生素D[25(OH)D]水平与慢性疼痛(CP)之间报道的关联存在不一致的原因尚未确定，但了解这种差异对于将补充维生素D作为CP的有效治疗方法的开发是必要的。这项横断面研究的目的是根据日本受试者的饮酒习惯来研究25(OH)D浓度与CP之间的关系。
患者与方法
我们向日本农村地区志贺町的2314名40岁以上个体发放了邀请函，招募了724名受试者(386名女性；平均年龄：63.9±10.4岁)。CP被定义为身体任何部位持续至少3个月的持续性疼痛。使用放射免疫分析法测量血清25(OH)D浓度，它是维生素D状态的生物标志物。血清25(OH)D水平<20 ng/mL被定义为血清25(OH)D缺乏。使用自填问卷评估饮酒习惯。有三个选项，“很少饮酒”、“有时饮酒”和“每天饮酒”。回答“很少饮酒”的受访者被标记为不饮酒者，其他受访者为饮酒者。
结果
CP的患病率为40.6%。观察到CP与饮酒习惯对25(OH)D浓度有显著交互作用(P = 0.098)。进行单因素协方差分析以比较每个饮酒组中有CP和无CP受试者之间的25(OH)D浓度，在饮酒者中，有CP受试者的血清25(OH)D水平显著低于无CP受试者(P = 0.007)。逻辑回归分析显示，在对几个混杂因素进行调整后，饮酒者血清25(OH)D缺乏与CP之间存在相关性(比值比：0.499；95%置信区间：0.268 - 0.927；P = 0.028)。
结论
目前的结果表明，血清25(OH)D浓度低与饮酒者CP的发生有关。
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