Spinal Unit, Emergency Hospital Cannizzaro, Catania, Italy.
Research Center "The Great Senescence", University of Catania, 95100 Catania, Italy.
Dis Markers. 2019 Mar 25;2019:3549402. doi: 10.1155/2019/3549402. eCollection 2019.
Statin-associated muscle symptoms are common side effects of statin therapy. These symptoms include myopathy, myalgia, and rhabdomyolysis. Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue. Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it.
This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status. These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS.
We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS). Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I. 71.6% to 81.7%) sensitivity and 63.4% (95% C.I. 60.2% to 66.5%) specificity in diagnosing SAMS. Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status.
We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.
他汀类药物相关肌肉症状是他汀类药物治疗的常见副作用。这些症状包括肌病、肌痛和横纹肌溶解症。维生素 D 与肌肉骨骼健康有关；因此，其缺乏可能对该组织产生不利影响。事实上，维生素 D 缺乏的一个症状是肌痛，而低维生素 D 水平的正常化可以缓解它。
这项横断面研究检查了 1210 名接受他汀类药物治疗的患者，以评估维生素 D 状况。这些患者分为两组：287 名有他汀类药物相关肌肉症状（SAMS）的患者和 923 名无 SAMS 的对照患者。
我们发现维生素 D 缺乏和不足状态与他汀类药物相关肌肉症状（SAMS）之间存在显著关联。维生素 D 缺乏（<30nmol/L）在诊断 SAMS 时具有 77%（95%置信区间 71.6%至 81.7%）的敏感性和 63.4%（95%置信区间 60.2%至 66.5%）的特异性。优势比分析表明，对于缺乏和不足状态，这种关联均为中强关联。
我们发现维生素 D 缺乏与 SAMS 之间存在相关性。因此，维生素 D 水平可能有助于 SAMS 的诊断和管理。
