Luo Guanshui, He Ke, Xia Zhenglin, Liu Shuai, Liu Hong, Xiang Guoan
Department of General Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong 510317, P.R. China.
Department of Postgraduate Studies, The Second Clinical College of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Oncol Lett. 2021 Jan;21(1):23. doi: 10.3892/ol.2020.12284. Epub 2020 Nov 11.
MicroRNAs (miRNAs/miRs) are a type of non-coding single-stranded RNA, with a length of ~22 nt, which are encoded by endogenous genes and are involved in the post-transcriptional regulation of gene expression in animals and plants. Studies have demonstrated that miRNAs play an important role in the occurrence, development, metastasis, diagnosis and treatment of cancer. In recent years, miR-497 has been identified as one of the key miRNAs in a variety of cancer types and has been shown to be downregulated in a variety of solid tumors. However, the regulation of miR-497 expression involves a complex network, which is affected by several factors. The aim of the present review was to summarize the mechanism of regulation of miR-497 expression at the pre-transcriptional and transcriptional levels in cancer, as well as the role of miR-497 expression imbalance in cancer diagnosis, treatment and prognosis. The regulatory mechanisms of miR-497 expression may aid in our understanding of the causes of miR-497 expression imbalance and provide a reference value for further research on the diagnosis and treatment of cancer.
微小RNA（miRNAs/miRs）是一类非编码单链RNA，长度约为22个核苷酸，由内源基因编码，参与动植物基因表达的转录后调控。研究表明，miRNAs在癌症的发生、发展、转移、诊断和治疗中发挥着重要作用。近年来，miR-497已被确定为多种癌症类型中的关键miRNAs之一，并且在多种实体瘤中呈下调表达。然而，miR-497表达的调控涉及一个复杂的网络，受多种因素影响。本综述的目的是总结癌症中miR-497在转录前和转录水平的表达调控机制，以及miR-497表达失衡在癌症诊断、治疗和预后中的作用。miR-497表达的调控机制可能有助于我们理解miR-497表达失衡的原因，并为癌症诊断和治疗的进一步研究提供参考价值。
