Angaran D
United Hospital Heart Institute, United Hospital, St. Paul, Minnesota 55102.
Pharmacotherapy. 1987;7(5 Pt 2):62S-71S. doi: 10.1002/j.1875-9114.1987.tb04052.x.
Calcium channel blockers, nitrates, and beta blockers are the primary agents used for the treatment of angina. Calcium has a central role in excitation-contraction, action potential generation, and ischemic cell death. The three currently available calcium antagonists are nifedipine, verapamil, and diltiazem. Second-generation agents are in development, and a classification system of calcium channel blockers is used to place the currently available agents and those on the horizon in perspective. Nitrate pharmacology and pharmacodynamics are possibly related to nitrate tolerance; however, this is a matter of some controversy. The beta blockers are all equally effective in the treatment of angina; therefore, drug selection is based on ancillary properties.
钙通道阻滞剂、硝酸盐类药物和β受体阻滞剂是治疗心绞痛的主要药物。钙在兴奋-收缩偶联、动作电位产生和缺血性细胞死亡中起核心作用。目前可用的三种钙拮抗剂是硝苯地平、维拉帕米和地尔硫䓬。第二代药物正在研发中，钙通道阻滞剂的分类系统用于对目前可用的药物以及即将出现的药物进行综合考量。硝酸盐类药物的药理作用和药效学可能与硝酸盐耐受性有关；然而，这存在一些争议。β受体阻滞剂在治疗心绞痛方面都同样有效；因此，药物选择基于其辅助特性。
