Heupler F A
Postgrad Med. 1984 May;75(6):127-32. doi: 10.1080/00325481.1984.11716314.
The calcium channel blocking drugs--nifedipine, verapamil, and diltiazem--are an important adjunct to treatment of typical exertional angina and are the treatment of choice for angina due to coronary artery spasm. These drugs are as effective as nitrates and beta-adrenergic blocking agents in treatment of patients with ischemic heart disease. With certain precautions, they may also be used in combination with nitrates and beta blockers. The three calcium blockers are not completely interchangeable because each has distinctive therapeutic applications and side effects. Detailed knowledge of each drug is important for its intelligent application in treatment of angina pectoris.
钙通道阻滞剂——硝苯地平、维拉帕米和地尔硫䓬——是治疗典型劳力性心绞痛的重要辅助药物，也是治疗冠状动脉痉挛所致心绞痛的首选药物。这些药物在治疗缺血性心脏病患者方面与硝酸盐类和β肾上腺素能阻滞剂同样有效。在采取某些预防措施的情况下，它们也可与硝酸盐类和β受体阻滞剂联合使用。这三种钙阻滞剂并非完全可相互替代，因为每种药物都有独特的治疗应用和副作用。详细了解每种药物对于其在心绞痛治疗中的明智应用非常重要。
