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参与泡沫细胞形成和动脉粥样硬化发展的基因及潜在机制分析。

Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis development.

作者信息

Zhang Kai, Qin Xianyu, Zhou Xianwu, Zhou Jianrong, Wen Pengju, Chen Shaoxian, Wu Min, Wu Yueheng, Zhuang Jian

机构信息

Department of Cardiovascular Surgery, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangdong Cardiovascular Institute, Guangzhou, Guangdong, China.

出版信息

PeerJ. 2020 Nov 17;8:e10336. doi: 10.7717/peerj.10336. eCollection 2020.

DOI:10.7717/peerj.10336
PMID:33240650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7678445/
Abstract

BACKGROUND

Foam cells (FCs) play crucial roles in the process of all stages of atherosclerosis. Smooth muscle cells (SMCs) and macrophages are the major sources of FCs. This study aimed to identify the common molecular mechanism in these two types of FCs.

METHODS

GSE28829, GSE43292, GSE68021, and GSE54666 were included to identify the differentially expressed genes (DEGs) associated with FCs derived from SMCs and macrophages. Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed by using the DAVID database. The co-regulated genes associated with the two origins of FCs were validated (GSE9874), and their expression in vulnerable atherosclerosis plaques (GSE120521 and GSE41571) was assessed.

RESULTS

A total of 432 genes associated with FCs derived from SMCs (SMC-FCs) and 81 genes associated with FCs derived from macrophages (M-FCs) were identified, and they were mainly involved in lipid metabolism, inflammation, cell cycle/apoptosis. Furthermore, three co-regulated genes associated with FCs were identified: , , and . These three common genes showed an increased tendency in unstable or ruptured plaques, although in some cases, no statistically significant difference was found.

CONCLUSIONS

DEGs related to FCs derived from SMCs and macrophages have contributed to the understanding of the molecular mechanism underlying the formation of FCs and atherosclerosis. , , and might be potential targets for atherosclerosis treatment.

摘要

背景

泡沫细胞（FCs）在动脉粥样硬化各个阶段的进程中发挥着关键作用。平滑肌细胞（SMCs）和巨噬细胞是泡沫细胞的主要来源。本研究旨在确定这两种类型泡沫细胞中的共同分子机制。

方法

纳入GSE28829、GSE43292、GSE68021和GSE54666数据集，以鉴定与源自平滑肌细胞和巨噬细胞的泡沫细胞相关的差异表达基因（DEGs）。使用DAVID数据库进行基因本体生物学过程（GO-BP）和京都基因与基因组百科全书（KEGG）通路分析。对与两种来源的泡沫细胞相关的共调控基因进行验证（GSE9874），并评估它们在易损动脉粥样硬化斑块中的表达（GSE120521和GSE41571）。

结果

共鉴定出432个与源自平滑肌细胞的泡沫细胞（SMC-FCs）相关的基因和81个与源自巨噬细胞的泡沫细胞（M-FCs）相关的基因，它们主要参与脂质代谢、炎症、细胞周期/凋亡。此外，鉴定出三个与泡沫细胞相关的共调控基因： 、 和 。这三个共同基因在不稳定或破裂斑块中呈现增加趋势，尽管在某些情况下未发现统计学显著差异。

结论

与源自平滑肌细胞和巨噬细胞的泡沫细胞相关的差异表达基因有助于理解泡沫细胞形成和动脉粥样硬化的分子机制。 、 和 可能是动脉粥样硬化治疗的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/46ba6da50dd3/peerj-08-10336-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/cd5014cd89ce/peerj-08-10336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/44702c062ea1/peerj-08-10336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/843027a4eded/peerj-08-10336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/d519e29b633a/peerj-08-10336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/02be6dcd38d1/peerj-08-10336-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/46ba6da50dd3/peerj-08-10336-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/cd5014cd89ce/peerj-08-10336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/44702c062ea1/peerj-08-10336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/843027a4eded/peerj-08-10336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/d519e29b633a/peerj-08-10336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/02be6dcd38d1/peerj-08-10336-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7183/7678445/46ba6da50dd3/peerj-08-10336-g006.jpg

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本文引用的文献

1
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J Food Biochem. 2020 Nov;44(11):e13449. doi: 10.1111/jfbc.13449. Epub 2020 Aug 27.
2
Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis.硫化氢供体在抗动脉粥样硬化中的治疗潜力。
Eur J Med Chem. 2020 Nov 1;205:112665. doi: 10.1016/j.ejmech.2020.112665. Epub 2020 Aug 3.
3
Signaling Pathways and Key Genes Involved in Regulation of foam Cell Formation in Atherosclerosis.
鉴定与动脉粥样硬化斑块不稳定性相关的单核细胞相关基因。
Oxid Med Cell Longev. 2022 Sep 21;2022:3972272. doi: 10.1155/2022/3972272. eCollection 2022.
4
From to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease.从到人：E3 连接酶 Godzilla 的生物学功能及其在疾病中的作用。
Cells. 2022 Jan 23;11(3):380. doi: 10.3390/cells11030380.
5
RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association.RNF13 亮氨酸-亮氨酸基序变体 L311S 和 L312P 干扰内体定位和 AP-3 复合物的结合。
Cells. 2021 Nov 6;10(11):3063. doi: 10.3390/cells10113063.
6
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J Clin Lab Anal. 2022 Jan;36(1):e24019. doi: 10.1002/jcla.24019. Epub 2021 Nov 26.
动脉粥样硬化中泡沫细胞形成的调控相关信号通路及关键基因。
Cells. 2020 Mar 1;9(3):584. doi: 10.3390/cells9030584.
4
Identification of genes and pathways related to atherosclerosis comorbidity and depressive behavior via RNA-seq and bioinformation analysis in ApoE mice.通过RNA测序和生物信息分析在载脂蛋白E基因敲除小鼠中鉴定与动脉粥样硬化合并症和抑郁行为相关的基因和通路
Ann Transl Med. 2019 Dec;7(23):733. doi: 10.21037/atm.2019.11.118.
5
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7
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Int J Mol Sci. 2019 Jul 20;20(14):3561. doi: 10.3390/ijms20143561.
8
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Lipids Health Dis. 2019 May 1;18(1):107. doi: 10.1186/s12944-019-1056-x.
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Arterioscler Thromb Vasc Biol. 2019 May;39(5):836-838. doi: 10.1161/ATVBAHA.119.312557.
10
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