治疗前循环中性粒细胞计数是口咽癌的一个独立预后因素。
Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer.
作者信息
Li Liang, Liu Guangping, Lu Honglue, Jin Kai, Zhai Xiang, Zhou Mengqian, Duan Yuansheng, Yue Kai, Wu Yansheng, Wang Xudong
机构信息
Department of Maxillofacial and E.N.T. Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Department of Otolaryngology, Tianjin Children's Hospital, Tianjin University Children's Hospital, Tianjin, China.
出版信息
Ann Transl Med. 2020 Sep;8(18):1135. doi: 10.21037/atm-20-5702.
BACKGROUND
Oropharyngeal cancer (OPC) is a type of head and neck squamous cell cancer, the incidence of which has increased in recent years. Many studies have reported a variety of prognostic markers of OPC, but they are either expensive or difficult to obtain. Therefore, we retrospectively studied the prognostic value of circulating neutrophil count (CNC) in patients with OPC, with the aim of providing a theoretical basis for further prognostic stratification.
METHODS
The clinicopathological data of 153 patients diagnosed with OPC from January 2010 to June 2017 were retrospectively analyzed. The CNC of each patient was measured before treatment. Then, the relationship between CNC and the clinicopathological characteristics of the patients was analyzed. The receiver operating characteristic (ROC) curve was used to calculate the cutoff value of CNC. The cox proportional hazards model was used to perform univariate and multivariate analysis of the relevant prognostic factors to determine the factors related to overall survival (OS) and progression-free survival (PFS).
RESULTS
The cutoff value for CNC was 4.48. Neutrophilia was significantly associated with disease stage, P16 status, and the type of therapy. In the univariate and multivariate analyses, CNC was found to be correlated with OS and PFS. Increased neutrophil count was predictive of poor OS (P<0.001) and PFS (P=0.001). Neutrophil count was an independent risk factor for OS (HR =2.09, 95% CI: 1.25-3.51, P=0.005) and PFS (HR =1.78, 95% CI: 1.10-2.88, P=0.02) in patients with OPC.
CONCLUSIONS
Pre-treatment CNC is an independent prognostic factor for OPC.
背景
口咽癌（OPC）是头颈部鳞状细胞癌的一种，近年来其发病率有所上升。许多研究报道了多种OPC的预后标志物，但它们要么昂贵，要么难以获取。因此，我们回顾性研究了循环中性粒细胞计数（CNC）在OPC患者中的预后价值，旨在为进一步的预后分层提供理论依据。
方法
回顾性分析2010年1月至2017年6月诊断为OPC的153例患者的临床病理资料。在治疗前测量每位患者的CNC。然后，分析CNC与患者临床病理特征之间的关系。采用受试者工作特征（ROC）曲线计算CNC的临界值。使用Cox比例风险模型对相关预后因素进行单因素和多因素分析，以确定与总生存期（OS）和无进展生存期（PFS）相关的因素。
结果
CNC的临界值为4.48。中性粒细胞增多与疾病分期、P16状态和治疗类型显著相关。在单因素和多因素分析中，发现CNC与OS和PFS相关。中性粒细胞计数增加预示着OS（P<0.001）和PFS（P=0.001）较差。中性粒细胞计数是OPC患者OS（HR =2.09，95%CI：1.25-3.51，P=0.005）和PFS（HR =1.78，95%CI：1.10-2.88，P=0.02）的独立危险因素。
结论
治疗前CNC是OPC的独立预后因素。
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