Supportive relationships with parents and friends reduce adolescent risk for depression; however, whether and how the strength of these associations changes across adolescence remains less clear. Age-varying associations of mother-adolescent and father-adolescent closeness and friend support with depressive symptoms were examined across ages 12.5-19.5 using data from the National Longitudinal Study of Adolescent to Adult Health (N = 4,819). Positive relationships with mothers, fathers, and friends were associated with lower depressive symptoms across adolescence, and the associations were generally stable across age. The association between father-adolescent closeness and depressive symptoms was stronger for girls than for boys during mid-adolescence. Mother-adolescent closeness was more strongly negatively associated with depressive symptoms in the context of higher friend support during mid-adolescence.