Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, No.107 Yanjiang West Road, Guangzhou 510120, China.
Regen Med. 2020 Sep;15(9):2067-2073. doi: 10.2217/rme-2020-0057. Epub 2020 Nov 26.
Osteonecrosis of femoral head (ONFH) is a disabling and intractable disease. Previous studies reported the increasing failure rates of total hip arthroplasty in younger patients, thus there should be special considerations for the adolescents. In this paper, we present a case of an adolescent female with late-stage glucocorticoid-induced ONFH (according to the Association Research Circulation Osseous classification system, Association Research Circulation Osseous IV). The patient received five consecutive ultrasound-guided intra-articular injections of platelet-rich plasma, and the therapeutic effects were assessed by visual analog scale, joint range of motion, Western Ontario and McMaster Universities Osteoarthritis Index, Harris Hip Score and magnetic resonance imaging. At 9-month follow-up, clinical and radiological reassessments demonstrated favorable outcomes. This case highlights the therapeutic potential of platelet-rich plasma injections for the late-stage ONFH, especially for adolescent patients.
股骨头坏死（ONFH）是一种致残性和难治性疾病。既往研究报道了年轻患者全髋关节置换术失败率的增加，因此青少年患者应特别考虑。本文报道了一例晚期糖皮质激素诱导的股骨头坏死（根据 Association Research Circulation Osseous 分类系统，Association Research Circulation Osseous IV 期）的青少年女性患者。患者接受了连续 5 次关节内超声引导富血小板血浆注射，通过视觉模拟评分、关节活动范围、西安大略和麦克马斯特大学骨关节炎指数、Harris 髋关节评分和磁共振成像评估治疗效果。9 个月随访时，临床和影像学评估结果良好。该病例强调了富血小板血浆注射治疗晚期 ONFH 的治疗潜力，特别是对青少年患者。
