土耳其 2 型糖尿病患者抗糖尿病药物使用的模式和偏好 - 一项全国性横断面研究（TEMD 治疗研究）。

Patterns and preferences of antidiabetic drug use in Turkish patients with type 2 diabetes - A nationwide cross-sectional study (TEMD treatment study).

机构信息

University of Health Sciences, Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.

University of Health Sciences, Gulhane School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.

出版信息

Diabetes Res Clin Pract. 2021 Jan;171:108556. doi: 10.1016/j.diabres.2020.108556. Epub 2020 Nov 24.

DOI:10.1016/j.diabres.2020.108556

PMID:33242516

Abstract

AIMS

The treatment preferences in type 2 diabetes (T2DM) are affected by multiple factors. This survey aims to find out the profiles of the utilization of antidiabetics and their determinants.

METHODS

The nationwide, multicenter TEMD survey consecutively enrolled patients with T2DM (n = 4678). Medications including oral antidiabetics (OAD) and injectable regimens were recorded. Multiple injectable regimens with or without OADs were defined as complex treatments.

RESULTS

A total of 4678 patients with T2DM (mean age: 58.5 ± 10.4 years, 59% female) were enrolled. More than half of patients (n = 2372; 50.7%) were using injectable regimens with or without OADs, and others (n = 2306, 49.3%) were using only OADs. The most common OADs were metformin (93.5%), secretagogues (40.1%), and DPP-4 inhibitors (37.2%). The rates of the use of basal, basal-bolus and premix insulin were 26.5%, 39.5% and 22.4%, respectively. Patients using OADs achieved better glycemia, blood pressure and weight control (p < 0.001 for all) but poorer LDL-C control (p < 0.001). The independent associates of complex treatments were diabetes duration, obesity, eGFR, glycated haemoglobin, macro and microvascular complications, education level, and self-reported hypoglycemia.

CONCLUSION

This study is the first nationwide report to show that almost half of the patients with T2DM are using injectable regimens in Turkey.

摘要

目的

2 型糖尿病（T2DM）的治疗偏好受多种因素影响。本调查旨在了解抗糖尿病药物的使用情况及其决定因素。

方法

这项全国性、多中心的 TEMD 调查连续纳入了 T2DM 患者（n=4678）。记录了包括口服降糖药（OAD）和注射方案在内的药物。有或没有 OAD 的多种注射方案被定义为复杂治疗。

结果

共纳入 4678 例 T2DM 患者（平均年龄：58.5±10.4 岁，59%为女性）。超过一半的患者（n=2372；50.7%）使用了有或没有 OAD 的注射方案，其余患者（n=2306，49.3%）仅使用 OAD。最常用的 OAD 是二甲双胍（93.5%）、促分泌素（40.1%）和 DPP-4 抑制剂（37.2%）。基础、基础-餐时和预混胰岛素的使用率分别为 26.5%、39.5%和 22.4%。使用 OAD 的患者血糖、血压和体重控制更好（p<0.001 均），但 LDL-C 控制更差（p<0.001）。复杂治疗的独立相关因素是糖尿病病程、肥胖、eGFR、糖化血红蛋白、大血管和微血管并发症、教育水平和自我报告的低血糖。