细胞因子风暴的不同特点：引发 COVID-19 的 SARS-CoV-2（新型冠状病毒）与引发 SARS 疫情的原始 SARS 病毒的细胞因子特征不同。
Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak.
机构信息
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, Division of Infectious Diseases, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
出版信息
J Glob Antimicrob Resist. 2021 Mar;24:90-92. doi: 10.1016/j.jgar.2020.11.005. Epub 2020 Nov 23.
Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients.
在这里，我们报告了三例 COVID-19（2019 年冠状病毒病）患者的病例系列，这些患者的细胞因子谱显示白细胞介素 6（IL-6）升高，但白细胞介素 10（IL-10）、干扰素-γ（INF-γ）和白细胞介素 8（IL-8）水平正常，与严重急性呼吸综合征（SARS）和中东呼吸综合征（MERS）中描述的细胞因子特征相反。我们还在其中两名患者中记录了 T 细胞 IFN-γ反应受损的证据。
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