新型冠状病毒2感染后抗趋化因子抗体与良好的病程相关。
Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course.
作者信息
Muri Jonathan, Cecchinato Valentina, Cavalli Andrea, Shanbhag Akanksha A, Matkovic Milos, Biggiogero Maira, Maida Pier Andrea, Moritz Jacques, Toscano Chiara, Ghovehoud Elaheh, Furlan Raffaello, Barbic Franca, Voza Antonio, Nadai Guendalina De, Cervia Carlo, Zurbuchen Yves, Taeschler Patrick, Murray Lilly A, Danelon-Sargenti Gabriela, Moro Simone, Gong Tao, Piffaretti Pietro, Bianchini Filippo, Crivelli Virginia, Podešvová Lucie, Pedotti Mattia, Jarrossay David, Sgrignani Jacopo, Thelen Sylvia, Uhr Mario, Bernasconi Enos, Rauch Andri, Manzo Antonio, Ciurea Adrian, Rocchi Marco B L, Varani Luca, Moser Bernhard, Bottazzi Barbara, Thelen Marcus, Fallon Brian A, Boyman Onur, Mantovani Alberto, Garzoni Christian, Franzetti-Pellanda Alessandra, Uguccioni Mariagrazia, Robbiani Davide F
机构信息
Institute for Research in Biomedicine, Università della Svizzera italiana; Bellinzona, Switzerland.
Swiss Institute of Bioinformatics; Lausanne, Switzerland.
出版信息
bioRxiv. 2022 Nov 27:2022.05.23.493121. doi: 10.1101/2022.05.23.493121.
UNLABELLED
Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 infection and autoimmune disorders, but they target different chemokines than those in COVID-19. Monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential.
ONE-SENTENCE SUMMARY: Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and predict lack of long COVID.
未标注
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染会导致多种症状，这些症状可能会持续数月。虽然抗病毒抗体具有保护作用，但那些针对干扰素和其他免疫因子的抗体与不良的新冠肺炎结局相关。相反，我们发现，新冠肺炎康复后，针对特定趋化因子的抗体普遍存在，与病情好转相关，且能预测感染后一年无长期新冠症状。抗趋化因子抗体在人类免疫缺陷病毒1（HIV-1）感染和自身免疫性疾病中也存在，但它们靶向的趋化因子与新冠肺炎中的不同。从新冠肺炎康复者体内获得的与趋化因子N环结合的单克隆抗体可损害细胞迁移。鉴于趋化因子在协调免疫细胞运输中的作用，与良好的新冠肺炎病情相关的天然产生的抗趋化因子抗体可能通过调节炎症反应而有益，因此具有治疗潜力。
一句话总结
天然产生的抗趋化因子抗体与良好的新冠肺炎病情相关，并可预测无长期新冠症状。
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