Department of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
The Women's Hospital of Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
BMC Urol. 2020 Nov 26;20(1):188. doi: 10.1186/s12894-020-00725-z.
It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females.
A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method.
Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP- groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP- groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05).
There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.
据报道，幽门螺杆菌（HP）感染在不孕人群中更为普遍。HP 感染可导致精子参数下降，而治疗 HP 感染可改善精子质量。然而，关于不孕与 HP 感染之间关系的研究仍然有限，需要更多的证据。因此，我们进行了本研究，旨在调查 HP 感染对男性精子质量和女性卵巢储备的影响。
本回顾性横断面研究纳入了 2016 年 1 月至 2019 年 6 月因腹部不适就诊于浙江大学第二医院并接受 C-尿素呼气 HP 检测的 16522 例患者。其中，过去 3 个月内进行过精子分析或卵巢储备检测的 565 例患者被纳入进一步分析。精子参数采用计算机辅助精子分析系统进行检测，血清抗苗勒管激素（AMH）和性激素采用电化学发光法进行检测。
在接受精子检测的 363 例患者中，136 例（37.47%）存在 HP 感染。在接受 AMH 检测的 202 例患者中，55 例（27.23%）存在 HP 感染。HP+组和 HP-组的精子浓度和活力无差异（P>0.05）。进一步的亚组分析按 5 岁年龄组分层，也证实精子参数无显著差异（P>0.05）。同时，与之前发表的数据汇总后，精子浓度或活力也无显著差异（P>0.05）。此外，本研究发现 HP+组和 HP-组的血清 AMH 水平相似（P>0.05）。进一步的亚组分析也证实血清 AMH 水平无显著差异（P>0.05）。
在中国患者中，基于 HP 感染史，精子参数和 AMH 水平无差异。
