Department of Optometry and Vision, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.
Department of Optometry and Vision, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain.
Cont Lens Anterior Eye. 2021 Oct;44(5):101384. doi: 10.1016/j.clae.2020.11.004. Epub 2020 Nov 23.
To evaluate visual function, ocular surface integrity and dry eye symptoms with an extended depth-of-focus (EDOF) design and a conventional multifocal (MF) contact lens (CL) after 15 days of wear.
A crossover single mask randomised clinical trial was conducted including 30 presbyopes who used an EDOF and a conventional MF CL (Biofinity MF) for 15 days each. Defocus curves, depth-of-focus range, contrast sensitivity (CS) under photopic and mesopic conditions (with and without glare) and subjective perception of halos and glare were evaluated. The ocular surface was evaluated through non-invasive Keratograph tear breakup time (NIKBUT), averaged tear breakup time (NIKBUT-avg), tear meniscus height (TMH), bulbar and limbal redness, and conjunctival and corneal staining. Dry eye symptoms were assessed with the OSDI questionnaire.
No statistically significant differences were found for defocus curves or depth-of-focus between the two CLs (both p > 0.05). Subjective perception of halos and glare was not significantly different between CLs. Statistically significant differences were observed for CS under mesopic conditions for low spatial frequencies (p = 0.008). None of the CL produced significant changes in NIKBUT, NIKBUT-avg, TMH or redness. No change in conjunctival staining was observed in 76.7 % and 73.3 % of participants for EDOF and Biofinity MF, respectively. No change in corneal staining was observed in 86.7 % and 83.3 % of participants for EDOF and Biofinity MF, respectively. No changes were observed in the symptomatology measured with OSDI questionnaire (p > 0.05).
Both CL for presbyopia offer good visual quality, preserve the ocular surface integrity and provide the patient with similar symptomatology levels after 15 days of lens wear.
评估使用扩展景深（EDOF）设计和传统多焦点（MF）隐形眼镜（CL）在佩戴 15 天后的视觉功能、眼表面完整性和干眼症状。
进行了一项交叉单盲随机临床试验，包括 30 名老视患者，他们分别使用 EDOF 和传统 MF CL（Biofinity MF）各 15 天。评估离焦曲线、景深范围、明适应和中间适应条件下（有无眩光）的对比敏感度（CS）以及对光晕和眩光的主观感知。通过非侵入性角膜染色破裂时间（NIKBUT）、平均破裂时间（NIKBUT-avg）、泪膜高度（TMH）、球结膜和角结膜充血、角膜和结膜染色评估眼表面。使用 OSDI 问卷评估干眼症状。
两种 CL 之间的离焦曲线或景深无统计学差异（均 p > 0.05）。CL 之间对光晕和眩光的主观感知无显著差异。低空间频率下中间适应条件下 CS 有统计学差异（p = 0.008）。两种 CL 均未引起 NIKBUT、NIKBUT-avg、TMH 或充血的显著变化。76.7%和 73.3%的 EDOF 和 Biofinity MF 患者分别观察到结膜染色无变化。86.7%和 83.3%的 EDOF 和 Biofinity MF 患者分别观察到角膜染色无变化。OSDI 问卷测量的症状无变化（p > 0.05）。
两种老视 CL 均可提供良好的视觉质量，保持眼表面完整性，并在佩戴 15 天后为患者提供相似的症状水平。
