Department of Intensive Care Unit, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Int Immunopharmacol. 2021 Jan;90:107160. doi: 10.1016/j.intimp.2020.107160. Epub 2020 Nov 24.
Septic cardiomyopathy (SCM)is common in septic patients and results in cardiovascular failure. The pathogenesis of SCM is complicated, and patients with SCM have high mortality because current treatment methods are limited. The cholinergic anti-inflammatory pathway (CAP) modulates inflammatory responses through vagus nerve stimulation that leads to the release of acetylcholine (ACh), which binds to the alpha7 nicotinic acetylcholine receptor (α7nAChR). Moreover, α7nAChR activation by its agonists at the tissue level inhibits inflammatory mediators and regulates the function of immune cells in sepsis. Therefore, the α7nAChR can maintain balance of the inflammatory-immune response in sepsis. CAP has been elucidated as a critical regulator of anti-inflammation in many diseases, including rheumatoid arthritis, inflammatory boweldisease and SCM. Additionally, some clinical and preclinical trials show therapeutic potential via regulating CAP. There are excellent studies regarding the beneficial role of CAP activation, especially α7nAChR, in experimental SCM. This review aims to discuss the CAP in attenuating inflammation and the potential role of α7nAChR activation in regulating immune and reducing inflammation in SCM.
脓毒症性心肌病（SCM）在脓毒症患者中很常见，可导致心血管衰竭。SCM 的发病机制很复杂，而且由于目前的治疗方法有限，SCM 患者的死亡率很高。胆碱能抗炎途径（CAP）通过刺激迷走神经释放乙酰胆碱（ACh）来调节炎症反应，ACh 与α7 烟碱型乙酰胆碱受体（α7nAChR）结合。此外，α7nAChR 激动剂在组织水平上的激活可抑制炎症介质并调节脓毒症中免疫细胞的功能。因此，α7nAChR 可以维持脓毒症中炎症-免疫反应的平衡。CAP 已被阐明为许多疾病（包括类风湿关节炎、炎症性肠病和 SCM）抗炎的关键调节剂。此外，一些临床和临床前研究表明，通过调节 CAP 具有治疗潜力。关于 CAP 激活在实验性 SCM 中的有益作用，特别是 α7nAChR 的激活，有很好的研究。本综述旨在讨论 CAP 在减轻炎症以及α7nAChR 激活在调节免疫和减轻 SCM 炎症中的潜在作用。
