胆碱能抗炎通路及其在脓毒症治疗中的作用。
Cholinergic anti-inflammatory pathway and its role in treatment of sepsis.
作者信息
Zi Shuangfeng, Li Jinghui, Liu Lei, Liu Furong
机构信息
Department of Critical Care Medicine, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Jan 28;45(1):68-73. doi: 10.11817/j.issn.1672-7347.2020.180651.
The cholinergic anti-inflammatory pathway (CAP) is a neuro-immunomodulatory pathway,in which acetylcholine (ACh) released by the interaction of vagal nerves with α7 nicotinic acetylcholine receptor (α7nAChR),which prevents the synthesis and release of pro-inflammatory cytokines and ultimately regulates the local or systemic inflammatory response in a feedback manner. It has been shown that there are many possible effective treatments for sepsis, including vagus nerve stimulation by physical therapy, drugs such as acetylcholine receptor agonist and ultrasound therapy.
胆碱能抗炎通路（CAP）是一条神经免疫调节通路，在该通路中，迷走神经与α7烟碱型乙酰胆碱受体（α7nAChR）相互作用释放乙酰胆碱（ACh），这可阻止促炎细胞因子的合成与释放，并最终以反馈方式调节局部或全身炎症反应。研究表明，脓毒症有多种可能有效的治疗方法，包括物理疗法刺激迷走神经、使用乙酰胆碱受体激动剂等药物以及超声疗法。
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