胎儿肝移植的概述与展望

Synopsis and prospectives on fetal liver transplantation.

作者信息

Gale R P, Touraine J L, Kochupillai V

机构信息

Hôpital Edouard Herriot, Lyon, France.

出版信息

Thymus. 1987;10(1-2):1-4. doi: 10.1007/978-94-009-3365-1_1.

DOI:10.1007/978-94-009-3365-1_1

PMID:3324398

Abstract

Over 300 individuals have received fetal liver transplants for a spectrum of disorders including immunodeficiencies, aplastic anemia, leukemia and genetic disorders. In some instances, the objective has been to reconstitute the immune system from fetal liver-derived lymphoid stem cells. In aplastic anemia and leukemia two distinct approaches have been used: engraftment of fetal liver-derived hematopoietic stem cells or attempts to stimulate recovery of autologous hematopoiesis via factors produced by fetal liver. In genetic disorders, partial engraftment of fetal liver-derived hematopoietic and hepatic cells has been investigated. This report critically reviews data presented at a symposium on fetal liver transplantation in New-Delhi, 1-5 February 1986.

摘要

已有300多名患者接受了胎儿肝脏移植，用于治疗一系列疾病，包括免疫缺陷、再生障碍性贫血、白血病和遗传性疾病。在某些情况下，目的是用胎儿肝脏来源的淋巴干细胞重建免疫系统。在再生障碍性贫血和白血病中，采用了两种不同的方法：移植胎儿肝脏来源的造血干细胞，或试图通过胎儿肝脏产生的因子刺激自体造血功能恢复。在遗传性疾病方面，已对胎儿肝脏来源的造血和肝细胞的部分植入进行了研究。本报告对1986年2月1日至5日在新德里举行的胎儿肝脏移植研讨会上所展示的数据进行了批判性回顾。