Jeonbuk Branch Institute, Korea Institute of Toxicology, 30 Baekhak1-gil, Jeongeup, Jeollabuk-do, 56212, Republic of Korea.
Sci Rep. 2020 Nov 26;10(1):20647. doi: 10.1038/s41598-020-76869-7.
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though perinatal exposure by the residual GLA in food might affect brain development, the developmental neurotoxicity of GLA is still unclear. Therefore, this study aimed to investigate the effects of perinatal exposure to GLA on cortical development. The analysis revealed that perinatal GLA exposure altered behavioral changes in offspring, especially motor functional behavior. Moreover, perinatal GLA exposure affected cortical development, particularly by disrupting interneuron migration. These results provide new evidence that early life exposure to GLA alters cortical development.
草铵膦（GLA）是一种用于农业杂草防治和作物脱水的广谱除草剂。由于许多抗草铵膦的作物被开发出来，以有效地控制杂草和提高收获产量，除草剂的使用和食品中的残留草铵膦显著增加。尽管食物中的残留草铵膦可能会影响大脑发育，但草铵膦的发育神经毒性仍不清楚。因此，本研究旨在探讨围产期暴露于草铵膦对皮质发育的影响。分析表明，围产期 GLA 暴露改变了后代的行为变化，特别是运动功能行为。此外，围产期 GLA 暴露还影响皮质发育，特别是通过干扰中间神经元的迁移。这些结果提供了新的证据，表明早期生活接触草铵膦会改变皮质发育。
